Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

Steric blocking peptide nucleic acid (PNA) oligonucleotides have been used increasingly for redirecting RNA splicing particularly in therapeutic applications such as Duchenne muscular dystrophy (DMD). Covalent attachment of a cell-penetrating peptide helps to improve cell delivery of PNA. We have us...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Ivanova, G, Arzumanov, A, Abes, R, Yin, H, Wood, M, Lebleu, B, Gait, M
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2008

Ижил төстэй зүйлс

Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.
-н: Hassane, F, зэрэг
Хэвлэсэн: (2011)

Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides.
-н: Andaloussi, S, зэрэг
Хэвлэсэн: (2011)

Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice.
-н: Yin, H, зэрэг
Хэвлэсэн: (2011)

Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice
-н: Yin, H, зэрэг
Хэвлэсэн: (2011)

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy
-н: Blain, A, зэрэг
Хэвлэсэн: (2018)

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy.
-н: Alison M Blain, зэрэг
Хэвлэсэн: (2018-01-01)

Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse.
-н: Lu, Q, зэрэг
Хэвлэсэн: (2003)

Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
-н: Gang Han, зэрэг
Хэвлэсэн: (2016-03-01)

Use of antisense-mediated exon skipping to generate dystrophin in muscles of the mdx dystrophic mouse
-н: Lu, Q, зэрэг
Хэвлэсэн: (2004)

Histone deacetylase inhibitors improve antisense-mediated exon-skipping efficacy in mdx mice
-н: Flavien Bizot, зэрэг
Хэвлэсэн: (2022-12-01)

In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse.
-н: Aoki, Y, зэрэг
Хэвлэсэн: (2010)

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment
-н: Betts, C, зэрэг
Хэвлэсэн: (2018)

Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery.
-н: Aoki, Y, зэрэг
Хэвлэсэн: (2012)

Efficient exon skipping by base-editor-mediated abrogation of exonic splicing enhancers
-н: Han Qiu, зэрэг
Хэвлэсэн: (2023-11-01)

Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays
-н: Yeh Ru-Fang, зэрэг
Хэвлэсэн: (2008-11-01)

Dynamic ASXL1 Exon Skipping and Alternative Circular Splicing in Single Human Cells.
-н: Winston Koh, зэрэг
Хэвлэсэн: (2016-01-01)

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment.
-н: Betts, C, зэрэг
Хэвлэсэн: (2012)

Oligonucleotide Enhancing Compound Increases Tricyclo-DNA Mediated Exon-Skipping Efficacy in the Mdx Mouse Model
-н: Flavien Bizot, зэрэг
Хэвлэсэн: (2023-02-01)

Nanopolymers improve delivery of exon skipping oligonucleotides and concomitant dystrophin expression in skeletal muscle of <it>mdx </it>mice
-н: Sirsi Shashank R, зэрэг
Хэвлэсэн: (2008-04-01)

Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse
-н: Glenn Dallérac, зэрэг
Хэвлэсэн: (2011-09-01)

Cationic polyelectrolyte-mediated delivery of antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice
-н: Wang M, зэрэг
Хэвлэсэн: (2015-09-01)

Good news for the mdx mouse community: Improved dystrophin restoration after skipping mouse dystrophin exon 23
-н: Annemieke Aartsma-Rus
Хэвлэсэн: (2022-12-01)

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion
-н: Yin, Hao, зэрэг
Хэвлэсэн: (2019)

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion
-н: Haiwei Mou, зэрэг
Хэвлэсэн: (2017-06-01)

A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice.
-н: Yin, H, зэрэг
Хэвлэсэн: (2009)

Networking to Optimize <i>Dmd</i> exon 53 Skipping in the Brain of <i>mdx52</i> Mouse Model
-н: Mathilde Doisy, зэрэг
Хэвлэсэн: (2023-12-01)

Exon skipping is correlated with exon circularization
-н: Kelly, S, зэрэг
Хэвлэсэн: (2015)

Reverse complementary matches simultaneously promote both back-splicing and exon-skipping
-н: Dong Cao
Хэвлэсэн: (2021-08-01)

Tristetraprolin specifically regulates the expression and alternative splicing of immune response genes in HeLa cells
-н: Yafang Tu, зэрэг
Хэвлэсэн: (2019-05-01)

Advancing the potential of peptide-PMO compounds in exon skipping therapy for DMD
-н: Godfrey, C, зэрэг
Хэвлэсэн: (2012)

Long-Term Efficacy of AAV9-U7snRNA-Mediated Exon 51 Skipping in mdx52 Mice
-н: Philippine Aupy, зэрэг
Хэвлэсэн: (2020-06-01)

Genetic characteristics of the HeLa cell.
-н: Hsu, S, зэрэг
Хэвлэсэн: (1976)

Triacylglycerol Measurement in HeLa Cells
-н: Ximing Du, зэрэг
Хэвлэсэн: (2020-12-01)

Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping
-н: Heegyum Moon, зэрэг
Хэвлэсэн: (2019-07-01)

Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse.
-н: Yin, H, зэрэг
Хэвлэсэн: (2010)

CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell
-н: Qingling Song, зэрэг
Хэвлэсэн: (2019-05-01)

Cell death in HeLa cells upon imperatorin and cisplatin treatment Cell death in HeLa cells upon imperatorin and cisplatin treatment
-н: Joanna Jakubowicz-Gil, зэрэг
Хэвлэсэн: (2012-10-01)

The size of chromatin loops in HeLa cells.
-н: Jackson, D, зэрэг
Хэвлэсэн: (1990)

Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice
-н: Ngoc Lu-Nguyen, зэрэг
Хэвлэсэн: (2017-03-01)

Cytotoxic activity of Galantamine hydrobromide against HeLa cell line
-н: Danka Obreshkova, зэрэг
Хэвлэсэн: (2023-08-01)