Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

Steric blocking peptide nucleic acid (PNA) oligonucleotides have been used increasingly for redirecting RNA splicing particularly in therapeutic applications such as Duchenne muscular dystrophy (DMD). Covalent attachment of a cell-penetrating peptide helps to improve cell delivery of PNA. We have us...

Bibliografske podrobnosti
Main Authors:	Ivanova, G, Arzumanov, A, Abes, R, Yin, H, Wood, M, Lebleu, B, Gait, M
Format:	Journal article
Jezik:	English
Izdano:	2008

Podobne knjige/članki

Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.
od: Hassane, F, et al.
Izdano: (2011)

Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides.
od: Andaloussi, S, et al.
Izdano: (2011)

Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice.
od: Yin, H, et al.
Izdano: (2011)

Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice
od: Yin, H, et al.
Izdano: (2011)

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy
od: Blain, A, et al.
Izdano: (2018)

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy.
od: Alison M Blain, et al.
Izdano: (2018-01-01)

Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse.
od: Lu, Q, et al.
Izdano: (2003)

Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
od: Gang Han, et al.
Izdano: (2016-03-01)

Use of antisense-mediated exon skipping to generate dystrophin in muscles of the mdx dystrophic mouse
od: Lu, Q, et al.
Izdano: (2004)

Histone deacetylase inhibitors improve antisense-mediated exon-skipping efficacy in mdx mice
od: Flavien Bizot, et al.
Izdano: (2022-12-01)

In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse.
od: Aoki, Y, et al.
Izdano: (2010)

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment
od: Betts, C, et al.
Izdano: (2018)

Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery.
od: Aoki, Y, et al.
Izdano: (2012)

Efficient exon skipping by base-editor-mediated abrogation of exonic splicing enhancers
od: Han Qiu, et al.
Izdano: (2023-11-01)

Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays
od: Yeh Ru-Fang, et al.
Izdano: (2008-11-01)

Dynamic ASXL1 Exon Skipping and Alternative Circular Splicing in Single Human Cells.
od: Winston Koh, et al.
Izdano: (2016-01-01)

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment.
od: Betts, C, et al.
Izdano: (2012)

Oligonucleotide Enhancing Compound Increases Tricyclo-DNA Mediated Exon-Skipping Efficacy in the Mdx Mouse Model
od: Flavien Bizot, et al.
Izdano: (2023-02-01)

Nanopolymers improve delivery of exon skipping oligonucleotides and concomitant dystrophin expression in skeletal muscle of <it>mdx </it>mice
od: Sirsi Shashank R, et al.
Izdano: (2008-04-01)

Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse
od: Glenn Dallérac, et al.
Izdano: (2011-09-01)

Cationic polyelectrolyte-mediated delivery of antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice
od: Wang M, et al.
Izdano: (2015-09-01)

Good news for the mdx mouse community: Improved dystrophin restoration after skipping mouse dystrophin exon 23
od: Annemieke Aartsma-Rus
Izdano: (2022-12-01)

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion
od: Yin, Hao, et al.
Izdano: (2019)

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion
od: Haiwei Mou, et al.
Izdano: (2017-06-01)

A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice.
od: Yin, H, et al.
Izdano: (2009)

Networking to Optimize <i>Dmd</i> exon 53 Skipping in the Brain of <i>mdx52</i> Mouse Model
od: Mathilde Doisy, et al.
Izdano: (2023-12-01)

Exon skipping is correlated with exon circularization
od: Kelly, S, et al.
Izdano: (2015)

Reverse complementary matches simultaneously promote both back-splicing and exon-skipping
od: Dong Cao
Izdano: (2021-08-01)

Tristetraprolin specifically regulates the expression and alternative splicing of immune response genes in HeLa cells
od: Yafang Tu, et al.
Izdano: (2019-05-01)

Advancing the potential of peptide-PMO compounds in exon skipping therapy for DMD
od: Godfrey, C, et al.
Izdano: (2012)

Long-Term Efficacy of AAV9-U7snRNA-Mediated Exon 51 Skipping in mdx52 Mice
od: Philippine Aupy, et al.
Izdano: (2020-06-01)

Genetic characteristics of the HeLa cell.
od: Hsu, S, et al.
Izdano: (1976)

Triacylglycerol Measurement in HeLa Cells
od: Ximing Du, et al.
Izdano: (2020-12-01)

Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping
od: Heegyum Moon, et al.
Izdano: (2019-07-01)

Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse.
od: Yin, H, et al.
Izdano: (2010)

CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell
od: Qingling Song, et al.
Izdano: (2019-05-01)

Cell death in HeLa cells upon imperatorin and cisplatin treatment Cell death in HeLa cells upon imperatorin and cisplatin treatment
od: Joanna Jakubowicz-Gil, et al.
Izdano: (2012-10-01)

The size of chromatin loops in HeLa cells.
od: Jackson, D, et al.
Izdano: (1990)

Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice
od: Ngoc Lu-Nguyen, et al.
Izdano: (2017-03-01)

Cytotoxic activity of Galantamine hydrobromide against HeLa cell line
od: Danka Obreshkova, et al.
Izdano: (2023-08-01)