The role of the p53 protein in the apoptotic response.
When mammalian cells or tissues are exposed to DNA damaging agents a programmed cell death pathway is induced as well as a cell cycle arrest. In mice in which the p53 gene has been inactivated by homologous recombination this response is profoundly diminished. These mice develop normally so that dev...
| Main Authors: | , , , |
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| Format: | Conference item |
| Published: |
1994
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