VEGF-D promotes the metastatic spread of tumor cells via the lymphatics.
Metastasis to local lymph nodes via the lymphatic vessels is a common step in the spread of solid tumors. To investigate the molecular mechanisms underlying the spread of cancer by the lymphatics, we examined the ability of vascular endothelial growth factor (VEGF)-D, a ligand for the lymphatic grow...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2001
|
| _version_ | 1797105235315916800 |
|---|---|
| author | Stacker, SA Caesar, C Baldwin, M Thornton, G Williams, R Prevo, R Jackson, D Nishikawa, S Kubo, H Achen, MG |
| author_facet | Stacker, SA Caesar, C Baldwin, M Thornton, G Williams, R Prevo, R Jackson, D Nishikawa, S Kubo, H Achen, MG |
| author_sort | Stacker, SA |
| collection | OXFORD |
| description | Metastasis to local lymph nodes via the lymphatic vessels is a common step in the spread of solid tumors. To investigate the molecular mechanisms underlying the spread of cancer by the lymphatics, we examined the ability of vascular endothelial growth factor (VEGF)-D, a ligand for the lymphatic growth factor receptor VEGFR-3/Flt-4, to induce formation of lymphatics in a mouse tumor model. Staining with markers specific for lymphatic endothelium demonstrated that VEGF-D induced the formation of lymphatics within tumors. Moreover, expression of VEGF-D in tumor cells led to spread of the tumor to lymph nodes, whereas expression of VEGF, an angiogenic growth factor which activates VEGFR-2 but not VEGFR-3, did not. VEGF-D also promoted tumor angiogenesis and growth. Lymphatic spread induced by VEGF-D could be blocked with an antibody specific for VEGF-D. This study demonstrates that lymphatics can be established in solid tumors and implicates VEGF family members in determining the route of metastatic spread. |
| first_indexed | 2024-03-07T06:44:36Z |
| format | Journal article |
| id | oxford-uuid:fa70aec8-6bd8-4508-8e2b-f16fc1575dbb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:44:36Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:fa70aec8-6bd8-4508-8e2b-f16fc1575dbb2022-03-27T13:05:51ZVEGF-D promotes the metastatic spread of tumor cells via the lymphatics.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fa70aec8-6bd8-4508-8e2b-f16fc1575dbbEnglishSymplectic Elements at Oxford2001Stacker, SACaesar, CBaldwin, MThornton, GWilliams, RPrevo, RJackson, DNishikawa, SKubo, HAchen, MGMetastasis to local lymph nodes via the lymphatic vessels is a common step in the spread of solid tumors. To investigate the molecular mechanisms underlying the spread of cancer by the lymphatics, we examined the ability of vascular endothelial growth factor (VEGF)-D, a ligand for the lymphatic growth factor receptor VEGFR-3/Flt-4, to induce formation of lymphatics in a mouse tumor model. Staining with markers specific for lymphatic endothelium demonstrated that VEGF-D induced the formation of lymphatics within tumors. Moreover, expression of VEGF-D in tumor cells led to spread of the tumor to lymph nodes, whereas expression of VEGF, an angiogenic growth factor which activates VEGFR-2 but not VEGFR-3, did not. VEGF-D also promoted tumor angiogenesis and growth. Lymphatic spread induced by VEGF-D could be blocked with an antibody specific for VEGF-D. This study demonstrates that lymphatics can be established in solid tumors and implicates VEGF family members in determining the route of metastatic spread. |
| spellingShingle | Stacker, SA Caesar, C Baldwin, M Thornton, G Williams, R Prevo, R Jackson, D Nishikawa, S Kubo, H Achen, MG VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. |
| title | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. |
| title_full | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. |
| title_fullStr | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. |
| title_full_unstemmed | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. |
| title_short | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. |
| title_sort | vegf d promotes the metastatic spread of tumor cells via the lymphatics |
| work_keys_str_mv | AT stackersa vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT caesarc vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT baldwinm vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT thorntong vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT williamsr vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT prevor vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT jacksond vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT nishikawas vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT kuboh vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics AT achenmg vegfdpromotesthemetastaticspreadoftumorcellsviathelymphatics |