Replacing, reducing and refining the use of animals in tuberculosis vaccine 1 research
Tuberculosis (TB) remains a serious global health threat and an improved vaccine is urgently needed. New candidate TB vaccines are tested using preclinical animal models such as mice, guinea pigs, cattle and non-human primates. Animals are routinely infected with virulent Mycobacterium tuberculos...
| প্রধান লেখক: | , |
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| বিন্যাস: | Journal article |
| প্রকাশিত: |
ALTEX Edition
2016
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| _version_ | 1826306232432984064 |
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| author | Tanner, R McShane, H |
| author_facet | Tanner, R McShane, H |
| author_sort | Tanner, R |
| collection | OXFORD |
| description | Tuberculosis (TB) remains a serious global health threat and an improved vaccine is urgently needed. New candidate TB vaccines are tested using preclinical animal models such as mice, guinea pigs, cattle and non-human primates. Animals are routinely infected with virulent Mycobacterium tuberculosis (M.tb) in challenge experiments to evaluate protective efficacy, raising ethical issues regarding the procedure of infection itself, symptoms of disease and humane end-points. We summarise the importance and limitations of animal models in TB vaccine research and review current alternatives and modifications in the context of the NC3Rs framework for replacing, reducing and refining the use of animals for scientific purposes. |
| first_indexed | 2024-03-07T06:44:49Z |
| format | Journal article |
| id | oxford-uuid:fa8181e1-a38a-400e-b2a7-f03cc53e94a0 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:44:49Z |
| publishDate | 2016 |
| publisher | ALTEX Edition |
| record_format | dspace |
| spelling | oxford-uuid:fa8181e1-a38a-400e-b2a7-f03cc53e94a02022-03-27T13:06:26ZReplacing, reducing and refining the use of animals in tuberculosis vaccine 1 researchJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fa8181e1-a38a-400e-b2a7-f03cc53e94a0Symplectic Elements at OxfordALTEX Edition2016Tanner, RMcShane, HTuberculosis (TB) remains a serious global health threat and an improved vaccine is urgently needed. New candidate TB vaccines are tested using preclinical animal models such as mice, guinea pigs, cattle and non-human primates. Animals are routinely infected with virulent Mycobacterium tuberculosis (M.tb) in challenge experiments to evaluate protective efficacy, raising ethical issues regarding the procedure of infection itself, symptoms of disease and humane end-points. We summarise the importance and limitations of animal models in TB vaccine research and review current alternatives and modifications in the context of the NC3Rs framework for replacing, reducing and refining the use of animals for scientific purposes. |
| spellingShingle | Tanner, R McShane, H Replacing, reducing and refining the use of animals in tuberculosis vaccine 1 research |
| title | Replacing, reducing and refining the use of animals in tuberculosis vaccine 1 research |
| title_full | Replacing, reducing and refining the use of animals in tuberculosis vaccine 1 research |
| title_fullStr | Replacing, reducing and refining the use of animals in tuberculosis vaccine 1 research |
| title_full_unstemmed | Replacing, reducing and refining the use of animals in tuberculosis vaccine 1 research |
| title_short | Replacing, reducing and refining the use of animals in tuberculosis vaccine 1 research |
| title_sort | replacing reducing and refining the use of animals in tuberculosis vaccine 1 research |
| work_keys_str_mv | AT tannerr replacingreducingandrefiningtheuseofanimalsintuberculosisvaccine1research AT mcshaneh replacingreducingandrefiningtheuseofanimalsintuberculosisvaccine1research |