PRPF8 defects cause missplicing in myeloid malignancies.

PRPF8 defects cause missplicing in myeloid malignancies.

Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most evolutionarily conserved spliceosomal protein. We identified either recurrent somatic PRPF8 mutations or hemizygous deletions in 15/447 and 24/450 cases, respectively. Fifty percen...

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Hlavní autoři: Kurtovic-Kozaric, A, Przychodzen, B, Singh, J, Konarska, M, Clemente, M, Otrock, Z, Nakashima, M, Hsi, E, Yoshida, K, Shiraishi, Y, Chiba, K, Tanaka, H, Miyano, S, Ogawa, S, Boultwood, J, Makishima, H, Maciejewski, J, Padgett, R
Médium: Journal article
Jazyk:English
Vydáno: 2015

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