Cohesin: its roles and mechanisms.
The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, A...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1826306279024361472 |
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| author | Nasmyth, K Haering, C |
| author_facet | Nasmyth, K Haering, C |
| author_sort | Nasmyth, K |
| collection | OXFORD |
| description | The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits. |
| first_indexed | 2024-03-07T06:45:32Z |
| format | Journal article |
| id | oxford-uuid:fabb975b-0634-496c-86a6-ae10ee0913e5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:45:32Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:fabb975b-0634-496c-86a6-ae10ee0913e52022-03-27T13:08:23ZCohesin: its roles and mechanisms.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fabb975b-0634-496c-86a6-ae10ee0913e5EnglishSymplectic Elements at Oxford2009Nasmyth, KHaering, CThe cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits. |
| spellingShingle | Nasmyth, K Haering, C Cohesin: its roles and mechanisms. |
| title | Cohesin: its roles and mechanisms. |
| title_full | Cohesin: its roles and mechanisms. |
| title_fullStr | Cohesin: its roles and mechanisms. |
| title_full_unstemmed | Cohesin: its roles and mechanisms. |
| title_short | Cohesin: its roles and mechanisms. |
| title_sort | cohesin its roles and mechanisms |
| work_keys_str_mv | AT nasmythk cohesinitsrolesandmechanisms AT haeringc cohesinitsrolesandmechanisms |