Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

Negative regulation of immune pathways is essential to achieve resolution of immune responses and to avoid excess inflammation. DNA stimulates type I IFN expression through the DNA sensor cGAS, the second messenger cGAMP, and the adaptor molecule STING Here, we report that STING degradation followin...

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Hlavní autoři: Prabakaran, T, Bodda, C, Krapp, C, Zhang, B-C, Christensen, MH, Sun, C, Reinert, L, Cai, Y, Jensen, SB, Skouboe, MK, Nyengaard, JR, Thompson, CB, Lebbink, RJ, Sen, GC, van Loo, G, Nielsen, R, Komatsu, M, Nejsum, LN, Jakobsen, MR, Gyrd-Hansen, M, Paludan, SR
Médium: Journal article
Jazyk:English
Vydáno: EMBO Press 2018

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