The application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry.
Imaging mass spectrometry is a powerful technique that allows chemical information to be correlated to a spatial coordinate on a sample. By using stigmatic ion microscopy, in conjunction with fast cameras, multiple ion masses can be imaged within a single experimental cycle. This means that fewer la...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797105368229216256 |
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| author | Brouard, M Halford, E Lauer, A Slater, C Winter, B Yuen, W John, J Hill, L Nomerotski, A Clark, A Crooks, J Sedgwick, I Turchetta, R Lee, J Vallance, C Wilman, E |
| author_facet | Brouard, M Halford, E Lauer, A Slater, C Winter, B Yuen, W John, J Hill, L Nomerotski, A Clark, A Crooks, J Sedgwick, I Turchetta, R Lee, J Vallance, C Wilman, E |
| author_sort | Brouard, M |
| collection | OXFORD |
| description | Imaging mass spectrometry is a powerful technique that allows chemical information to be correlated to a spatial coordinate on a sample. By using stigmatic ion microscopy, in conjunction with fast cameras, multiple ion masses can be imaged within a single experimental cycle. This means that fewer laser shots and acquisition cycles are required to obtain a full data set, and samples suffer less degradation as overall collection time is reduced. We present the first spatial imaging mass spectrometry results obtained with a new time-stamping detector, named the pixel imaging mass spectrometry (PImMS) sensor. The sensor is capable of storing multiple time stamps in each pixel for each time-of-flight cycle, which gives it multi-mass imaging capabilities within each pixel. A standard velocity-map ion imaging apparatus was modified to allow for microscope mode spatial imaging of a large sample area (approximately 5 × 5 mm(2)). A variety of samples were imaged using PImMS and a conventional camera to determine the specifications and possible applications of the spectrometer and the PImMS camera. |
| first_indexed | 2024-03-07T06:46:31Z |
| format | Journal article |
| id | oxford-uuid:fb06cb03-a6f9-4c3b-b6f5-621397bfe049 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:46:31Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:fb06cb03-a6f9-4c3b-b6f5-621397bfe0492022-03-27T13:10:51ZThe application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fb06cb03-a6f9-4c3b-b6f5-621397bfe049EnglishSymplectic Elements at Oxford2012Brouard, MHalford, ELauer, ASlater, CWinter, BYuen, WJohn, JHill, LNomerotski, AClark, ACrooks, JSedgwick, ITurchetta, RLee, JVallance, CWilman, EImaging mass spectrometry is a powerful technique that allows chemical information to be correlated to a spatial coordinate on a sample. By using stigmatic ion microscopy, in conjunction with fast cameras, multiple ion masses can be imaged within a single experimental cycle. This means that fewer laser shots and acquisition cycles are required to obtain a full data set, and samples suffer less degradation as overall collection time is reduced. We present the first spatial imaging mass spectrometry results obtained with a new time-stamping detector, named the pixel imaging mass spectrometry (PImMS) sensor. The sensor is capable of storing multiple time stamps in each pixel for each time-of-flight cycle, which gives it multi-mass imaging capabilities within each pixel. A standard velocity-map ion imaging apparatus was modified to allow for microscope mode spatial imaging of a large sample area (approximately 5 × 5 mm(2)). A variety of samples were imaged using PImMS and a conventional camera to determine the specifications and possible applications of the spectrometer and the PImMS camera. |
| spellingShingle | Brouard, M Halford, E Lauer, A Slater, C Winter, B Yuen, W John, J Hill, L Nomerotski, A Clark, A Crooks, J Sedgwick, I Turchetta, R Lee, J Vallance, C Wilman, E The application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry. |
| title | The application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry. |
| title_full | The application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry. |
| title_fullStr | The application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry. |
| title_full_unstemmed | The application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry. |
| title_short | The application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry. |
| title_sort | application of the fast multi hit pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry |
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