Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria.
An open paired randomised comparison of intramuscular chloroquine (3.5 mg base/kg every 6 h) and intramuscular quinine (20 mg salt/kg followed by 10 mg/kg every 12 h) was carried out in 50 Gambian children with severe falciparum malaria. 8 children died, 6 from the quinine-treated and 2 from the chl...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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| _version_ | 1797105373472096256 |
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| author | White, N Krishna, S Waller, D Craddock, C Kwiatkowski, D Brewster, D |
| author_facet | White, N Krishna, S Waller, D Craddock, C Kwiatkowski, D Brewster, D |
| author_sort | White, N |
| collection | OXFORD |
| description | An open paired randomised comparison of intramuscular chloroquine (3.5 mg base/kg every 6 h) and intramuscular quinine (20 mg salt/kg followed by 10 mg/kg every 12 h) was carried out in 50 Gambian children with severe falciparum malaria. 8 children died, 6 from the quinine-treated and 2 from the chloroquine-treated group. Chloroquine reduced parasitaemia significantly more rapidly than did quinine, but other measures of the therapeutic response were similar in the two groups. Quinine injections were painful. These findings do not support the proposition that quinine is intrinsically superior to chloroquine in the treatment of severe drug-sensitive falciparum malaria. |
| first_indexed | 2024-03-07T06:46:36Z |
| format | Journal article |
| id | oxford-uuid:fb0fb399-dd50-485e-b173-808425461fce |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:46:36Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:fb0fb399-dd50-485e-b173-808425461fce2022-03-27T13:11:07ZOpen comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fb0fb399-dd50-485e-b173-808425461fceEnglishSymplectic Elements at Oxford1989White, NKrishna, SWaller, DCraddock, CKwiatkowski, DBrewster, DAn open paired randomised comparison of intramuscular chloroquine (3.5 mg base/kg every 6 h) and intramuscular quinine (20 mg salt/kg followed by 10 mg/kg every 12 h) was carried out in 50 Gambian children with severe falciparum malaria. 8 children died, 6 from the quinine-treated and 2 from the chloroquine-treated group. Chloroquine reduced parasitaemia significantly more rapidly than did quinine, but other measures of the therapeutic response were similar in the two groups. Quinine injections were painful. These findings do not support the proposition that quinine is intrinsically superior to chloroquine in the treatment of severe drug-sensitive falciparum malaria. |
| spellingShingle | White, N Krishna, S Waller, D Craddock, C Kwiatkowski, D Brewster, D Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. |
| title | Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. |
| title_full | Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. |
| title_fullStr | Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. |
| title_full_unstemmed | Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. |
| title_short | Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. |
| title_sort | open comparison of intramuscular chloroquine and quinine in children with severe chloroquine sensitive falciparum malaria |
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