IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.
Interferon (IFN)-gamma is a critical mediator of immunity to malaria. This study explored the relationship between polymorphisms in the promoter region of the gene encoding IFN-gamma receptor 1 (IFNGR1) and susceptibility to malaria in African children. Four polymorphisms were found in the region be...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2002
|
| _version_ | 1826306396918906880 |
|---|---|
| author | Koch, O Awomoyi, A Usen, S Jallow, M Richardson, A Hull, J Pinder, M Newport, M Kwiatkowski, D |
| author_facet | Koch, O Awomoyi, A Usen, S Jallow, M Richardson, A Hull, J Pinder, M Newport, M Kwiatkowski, D |
| author_sort | Koch, O |
| collection | OXFORD |
| description | Interferon (IFN)-gamma is a critical mediator of immunity to malaria. This study explored the relationship between polymorphisms in the promoter region of the gene encoding IFN-gamma receptor 1 (IFNGR1) and susceptibility to malaria in African children. Four polymorphisms were found in the region between -1400 and +100 nt of the translational start site by sequencing, and analysis of 562 nuclear families revealed 6 haplotypes. Case-control analysis of 562 Gambian children with severe malaria and 569 umbilical cord blood samples (controls) showed that in Mandinka, the major Gambian ethnic group, heterozygotes for the IFNGR1-56 polymorphism were protected against cerebral malaria (odds ratio, 0.54; P=.016) and against death resulting from cerebral malaria (odds ratio, 0.22; P=.006). Analysis of a family study by transmission disequilibrium testing revealed a similar result. Further data are needed to validate this finding, but these results are reminiscent of those for other well-established heterozygote advantages, such as that associated with hemoglobin S. |
| first_indexed | 2024-03-07T06:47:21Z |
| format | Journal article |
| id | oxford-uuid:fb4ffb25-2164-43d6-8c10-1d18503badc8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:47:21Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:fb4ffb25-2164-43d6-8c10-1d18503badc82022-03-27T13:12:49ZIFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fb4ffb25-2164-43d6-8c10-1d18503badc8EnglishSymplectic Elements at Oxford2002Koch, OAwomoyi, AUsen, SJallow, MRichardson, AHull, JPinder, MNewport, MKwiatkowski, DInterferon (IFN)-gamma is a critical mediator of immunity to malaria. This study explored the relationship between polymorphisms in the promoter region of the gene encoding IFN-gamma receptor 1 (IFNGR1) and susceptibility to malaria in African children. Four polymorphisms were found in the region between -1400 and +100 nt of the translational start site by sequencing, and analysis of 562 nuclear families revealed 6 haplotypes. Case-control analysis of 562 Gambian children with severe malaria and 569 umbilical cord blood samples (controls) showed that in Mandinka, the major Gambian ethnic group, heterozygotes for the IFNGR1-56 polymorphism were protected against cerebral malaria (odds ratio, 0.54; P=.016) and against death resulting from cerebral malaria (odds ratio, 0.22; P=.006). Analysis of a family study by transmission disequilibrium testing revealed a similar result. Further data are needed to validate this finding, but these results are reminiscent of those for other well-established heterozygote advantages, such as that associated with hemoglobin S. |
| spellingShingle | Koch, O Awomoyi, A Usen, S Jallow, M Richardson, A Hull, J Pinder, M Newport, M Kwiatkowski, D IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. |
| title | IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. |
| title_full | IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. |
| title_fullStr | IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. |
| title_full_unstemmed | IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. |
| title_short | IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. |
| title_sort | ifngr1 gene promoter polymorphisms and susceptibility to cerebral malaria |
| work_keys_str_mv | AT kocho ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria AT awomoyia ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria AT usens ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria AT jallowm ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria AT richardsona ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria AT hullj ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria AT pinderm ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria AT newportm ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria AT kwiatkowskid ifngr1genepromoterpolymorphismsandsusceptibilitytocerebralmalaria |