Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites.
When selection is strong and beneficial alleles have a single origin, local reductions in genetic diversity are expected. However, when beneficial alleles have multiple origins or were segregating in the population prior to a change in selection regime, the impact on genetic diversity may be less cl...
Main Authors: | Nair, S, Nash, D, Sudimack, D, Jaidee, A, Barends, M, Uhlemann, A, Krishna, S, Nosten, F, Anderson, T |
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Format: | Journal article |
Jezik: | English |
Izdano: |
2007
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