Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).

Bibliographic Details
Main Authors:	Ebetino, F, Rogers, M, Dunford, J, Liu, X, Phipps, R, Russell, R, Mieling, G, Barnett, B
Format:	Conference item
Published:	2002

Similar Items

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2002)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
by: Ebetino, F, et al.
Published: (2002)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2005)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
by: Dunford, J, et al.
Published: (2006)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2007)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
by: Evdokimov, A, et al.
Published: (2006)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
by: Xia, Z, et al.
Published: (2007)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
by: Ebetino, F, et al.
Published: (2006)

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
by: Ebetino, F, et al.
Published: (2007)

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
by: Kavanagh, K, et al.
Published: (2005)

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
by: Dunford, J, et al.
Published: (2006)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
by: Xia, Z, et al.
Published: (2006)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
by: Dunford, J, et al.
Published: (2007)

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates
by: Dunford, J, et al.
Published: (2008)

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
by: Dunford, J, et al.
Published: (2008)

Polymorphic variation in the FPP synthase (FPPS) gene and effects on bisphosphonate inhibition
by: Roemelt, C, et al.
Published: (2007)

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
by: Dunford, J, et al.
Published: (2008)

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
by: Kwassi, A, et al.
Published: (2009)

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
by: Ebetino, F, et al.
Published: (2008)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
by: Dunford, J, et al.
Published: (2007)

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
by: Ebetino, F, et al.
Published: (2006)

MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase
by: Hogan, J, et al.
Published: (2007)

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
by: Dunford, J, et al.
Published: (2008)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
by: Dunford, J, et al.
Published: (2008)

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
by: Tsoumpra, M, et al.
Published: (2010)

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
by: Kavanagh, K, et al.
Published: (2006)

Bisphosphonate affinity to hydroxyapatite and farnesyl pyrophosphate inhibitory potency, together, drive in vivo efficacy
by: Lundy, M, et al.
Published: (2007)

The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity.
by: Ebetino, F, et al.
Published: (2013)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
by: Räikkönen, J, et al.
Published: (2011)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
by: Räikkönen, J, et al.
Published: (2011)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
by: Tsoumpra, MK, et al.
Published: (2015)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
by: Tsoumpra, M, et al.
Published: (2015)

Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition.
by: Dunford, J
Published: (2010)

Why do some patients fail to respond to bisphosphonate therapy: Identification of a novel polymorphism in exon 11 of FPP synthase
by: Roemelt, C, et al.
Published: (2007)

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
by: Kavanagh, K, et al.
Published: (2006)

Differences between bisphosphonates in binding affinities for hydroxyapatite.
by: Lawson, M, et al.
Published: (2010)

Differentiation of bisphosphonates based on their physical chemical properties
by: Phipps, R, et al.
Published: (2006)

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
by: Artz, J, et al.
Published: (2008)

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.
by: Artz, J, et al.
Published: (2008)