Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Mostra altre versioni (1)

Ferrous ion and 2-oxoglutarate (2OG) oxygenases catalyze the demethylation of N(epsilon)-methylated lysine residues in histones. Here we report studies on the inhibition of the JMJD2 subfamily of histone demethylases, employing binding analyses by nondenaturing mass spectrometry (MS), dynamic combin...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Rose, N, Woon, E, Kingham, G, King, O, Mecinović, J, Clifton, I, Ng, S, Talib-Hardy, J, Oppermann, U, McDonough, M, Schofield, C
Natura:	Journal article
Lingua:	English
Pubblicazione:	2010
Soggetti:	Binding, Competitive Spectrometry, Mass, Electrospray Ionization Binding Sites analogs and derivatives chemistry Tyrosine Structure-Activity Relationship Crystallography, X-Ray chemical synthesis Models, Molecular Combinatorial Chemistry Techniques Oxalic Acids antagonists and inhibitors Jumonji Domain-Containing Histone Demethylases Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Documenti analoghi

A targeted mass spectrometric analysis of phosphatidylinositol phosphate species
di: Stephen B. Milne, et al.
Pubblicazione: (2005-08-01)

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
di: Rose, N, et al.
Pubblicazione: (2010)

Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples
di: Xianlin Han, et al.
Pubblicazione: (2006-04-01)

Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals
di: Manman Qin, et al.
Pubblicazione: (2023-01-01)

Investigating the regulation of membrane protein assemblies by lipids and other small molecules using native mass spectrometry
di: Shutin, D
Pubblicazione: (2020)

Protein phosphorylation analysis by electrospray mass spectrometry : a guide to concepts and practice /
di: 507924 Lehmann, Wolf D.
Pubblicazione: (2011)

Chemical reactivity hazard training [electronic resource] /
Pubblicazione: (2006)

Espectrometria de massas com ionização por "electrospray": processos químicos envolvidos na formação de íons de substâncias orgânicas de baixo peso molecular
di: Crotti Antônio Eduardo Miller, et al.
Pubblicazione: (2006-01-01)

Study on the Structural Effect of Maltoligosaccharides on Cytochrome c Complexes Stabilities by Native Mass Spectrometry
di: Quan Chi, et al.
Pubblicazione: (2018-01-01)

Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis
di: Jiafa Zeng, et al.
Pubblicazione: (2022-02-01)

Seminolipid and its precursor/degradative product, galactosylalkylacylglycerol, in the testis of saposin A- and prosaposin-deficient mice
di: Keiko Tadano-Aritomi, et al.
Pubblicazione: (2003-09-01)

A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A
di: Andrew J. Norris, et al.
Pubblicazione: (2005-10-01)

Characterization of Nucleosides and Nucleobases in Natural Cordyceps by HILIC–ESI/TOF/MS and HILIC–ESI/MS
di: Bin Yang, et al.
Pubblicazione: (2013-08-01)

Detection of Plasmodium vivax in a child returning from India by use of broad-range PCR and electrospray ionization mass spectrometry
di: Megan A Rounds, et al.
Pubblicazione: (2012-07-01)

Estudo por espectrometria de massas de soluções de hidróxi(tosilóxi)iodobenzeno: propostas para mecanismos de desproporção
di: Ramon S. Vasconcelos, et al.
Pubblicazione: (2012-01-01)

Identification of phosphatidylserylglutamate: a novel minor lipid in Escherichia coli
di: Teresa A. Garrett, et al.
Pubblicazione: (2009-08-01)

Copper complexes formed by 3,5-bis(2,2′-bipyridin-4-ylethynyl)benzoic acid and its methyl and ethyl esters as studied by electrospray ionization mass spectrometry
di: Frański Rafał, et al.
Pubblicazione: (2013-12-01)

Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS)
di: G. Liebisch, et al.
Pubblicazione: (1999-08-01)

ESI-MS spectra of 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)-pyridinones
di: BRATISLAV Ž. JOVANOVIĆ, et al.
Pubblicazione: (2009-03-01)

Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells
di: Anthony D. Postle, et al.
Pubblicazione: (2006-06-01)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
di: Sakurai, M, et al.
Pubblicazione: (2010)

Electrospray ionization mass spectrometric study of mercury complexes of N-heterocyclic carbenes derived from 1,2,4-triazolium salt precursors
di: Frański Rafał, et al.
Pubblicazione: (2007-03-01)

DMS as an orthogonal separation to LC/ESI/MS/MS for quantifying isomeric cerebrosides in plasma and cerebrospinal fluid[S]
di: Hongbin Xu, et al.
Pubblicazione: (2019-01-01)

Structural Characterization of Flavonoid Glycoconjugates and Their Derivatives with Mass Spectrometric Techniques
di: Piotr Kachlicki, et al.
Pubblicazione: (2016-11-01)

Identification of Endocrine-Disrupting Compounds Using Nanoelectrospray Ionization Mass Spectrometry
di: Cédric Bovet, et al.
Pubblicazione: (2008-05-01)

Moderate Signal Enhancement in Electrospray Ionization Mass Spectrometry by Focusing Electrospray Plume with a Dielectric Layer around the Mass Spectrometer’s Orifice
di: Zi Qing Chua, et al.
Pubblicazione: (2024-01-01)

Preparing Apigenin from Leaves of Adinandra nitida
di: Zhengxiang Ning, et al.
Pubblicazione: (2008-01-01)

Comment on Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an <i>Achillea millefolium</i> L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against <i>Helicobacter pylori</i>. <i>Antioxidants</i> 2022, <i>11</i>, 1849
di: Rafał Frański, et al.
Pubblicazione: (2023-06-01)

Analytical Performance Evaluation of New DESI Enhancements for Targeted Drug Quantification in Tissue Sections
di: Margaux Fresnais, et al.
Pubblicazione: (2022-06-01)

Accurate Quantification of Lipid Species by Electrospray Ionization Mass Spectrometry — Meets a Key Challenge in Lipidomics
di: Kui Yang, et al.
Pubblicazione: (2011-11-01)

Recent advancements in nanoelectrospray ionization interface and coupled devices
di: Shiyi Chen, et al.
Pubblicazione: (2022-11-01)

Fabricating an Electrospray Ionization Chip Based on Induced Polarization and Liquid Splitting
di: Lvhan Zhou, et al.
Pubblicazione: (2021-08-01)

Chromium interaction with O-donor humic-like ligands using electrospray-ionization mass spectrometry
di: Anđelković Darko H., et al.
Pubblicazione: (2013-01-01)

Overcharging Effect in Electrospray Ionization Mass Spectra of Daunomycin-Tuftsin Bioconjugates
di: Lilla Pethő, et al.
Pubblicazione: (2019-08-01)

Toward Depth-Resolved Analysis of Plant Metabolites by Nanospray Desorption Electrospray Ionization Mass Spectrometry
di: Sangwon Cha, et al.
Pubblicazione: (2022-11-01)

Examining Interactions of Uranyl(VI) Ions with Amino Acids in the Gas Phase
di: Ana F. Lucena, et al.
Pubblicazione: (2023-03-01)

Detecting Intermediates and Products of Fast Heterogeneous Reactions on Liquid Surfaces via Online Mass Spectrometry
di: Agustín J. Colussi, et al.
Pubblicazione: (2019-01-01)

Electrospray mass spectrometry of human hair wax esters
di: Fitzgerald Mark, et al.
Pubblicazione: (2007-05-01)

Shotgun lipidomics of phosphoethanolamine-containing lipids in biological samples after one-step in situ derivatization
di: Xianlin Han, et al.
Pubblicazione: (2005-07-01)

Ambient ionization mass spectrometry /
di: Cody, Robert, et al.
Pubblicazione: (2015)