A dynamic model of excitation−contraction coupling during acidosis in cardiac ventricular myocytes
Acidosis in cardiac myocytes is a major factor in the reduced inotropy that occurs in the ischemic heart. During acidosis, diastolic calcium concentration and the amplitude of the calcium transient increase, while the strength of contraction decreases. This has been attributed to the inhibition by p...
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| 格式: | Journal article |
| 出版: |
2006
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