Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1.

Endothelin-1 (ET-1) is a potent G(q)-coupled agonist with important physiological effects on the heart. In the present study, we characterised the effect of prolonged ET-1 stimulation on Ca(2+) signalling within acutely isolated atrial myocytes. ET-1 induced a reproducible and complex sequence of ef...

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Bibliographic Details
Main Authors: Bootman, MD, Harzheim, D, Smyrnias, I, Conway, S, Roderick, H
Format: Journal article
Language:English
Published: 2007