Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1.
Endothelin-1 (ET-1) is a potent G(q)-coupled agonist with important physiological effects on the heart. In the present study, we characterised the effect of prolonged ET-1 stimulation on Ca(2+) signalling within acutely isolated atrial myocytes. ET-1 induced a reproducible and complex sequence of ef...
Main Authors: | Bootman, MD, Harzheim, D, Smyrnias, I, Conway, S, Roderick, H |
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Format: | Journal article |
Language: | English |
Published: |
2007
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