Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation

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Rationale: Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthases (NOS). Oral BH4 supplementation preserves cardiac function in animal models of cardiac disease; however, the mechanisms underlying these findings are not completely understood. Objective: To study the effect of m...

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Bibliographic Details
Main Authors:	Carnicer, R, Hale, AB, Suffredini, S, Liu, X, Reilly, S, Zhang, M, Surdo, N, Bendall, J, Crabtree, M, Lim, G, Alp, N, Channon, K, Casadei, B
Format:	Journal article
Language:	English
Published:	2012

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