Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection.
A transgenic mouse expressing MHC class II-restricted TCR with specificity for a lymphocytic choriomeningitis virus (LCMV) glycoprotein-derived T helper cell epitope was developed to study the role of LCMV-specific CD4+ T cells in virus infection in vivo. The majority of CD4+ T cells in TCR transgen...
Váldodahkkit: | Oxenius, A, Bachmann, M, Zinkernagel, R, Hengartner, H |
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Materiálatiipa: | Journal article |
Giella: | English |
Almmustuhtton: |
1998
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Geahča maid
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Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.
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Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system.
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TAP1-independent loading of class I molecules by exogenous viral proteins.
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Almmustuhtton: (2023)