The chromatin remodeller ATRX: a repeat offender in human disease.

The chromatin remodeller ATRX: a repeat offender in human disease.

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The regulation of chromatin structure is of paramount importance for a variety of fundamental nuclear processes, including gene expression, DNA repair, replication, and recombination. The ATP-dependent chromatin-remodelling factor ATRX (α thalassaemia/mental retardation X-linked) has emerged as a ke...

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Xehetasun bibliografikoak
Egile Nagusiak:	Clynes, D, Higgs, D, Gibbons, R
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Cell Press 2013

Antzeko izenburuak

The chromatin remodeller ATRX: A repeat offender in human disease
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ATRX: taming tandem repeats.
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The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.
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ATRX and the replication of structured DNA.
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Recognition of the nucleosome by the chromatin remodeler atrx
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Identification of acquired somatic mutations in the chromatin remodelling factor ATRX in the a thalassaemia myelodysplasia syndrome (ATMDS)
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The role of chromatin remodeller ATRX in gene expression
nork: Shen, Y
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Identification of acquired somatic mutations in the chromatin remodelling factor ATRX in the alpha thalassemia myelodysplasia syndrome (ATMDS).
nork: Gibbons, R, et al.
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The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.
nork: Xue, Y, et al.
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Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
nork: Argentaro, A, et al.
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Role of the chromatin remodeler ATRX in the regulation of gene expression
nork: Truch, J
Argitaratua: (2018)

Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).
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The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin
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The chromatin remodelling factor dATRX is involved in heterochromatin formation.
nork: Andrew R Bassett, et al.
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Mutations in the chromatin-associated protein ATRX.
nork: Gibbons, R, et al.
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The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin
nork: Julia Truch, et al.
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ATRX dysfunction induces replication defects in primary mouse cells
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A novel splicing mutation in the gene encoding the chromatin-associated factor ATRX associated with acquired hemoglobin H disease in myelodysplastic syndrome (ATMDS)
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How does the chromatin remodeler ATRX identify its targets in the genome?
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XNP/ATRX at sites of nucleosome replacement.
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Identification of mutations in ATRX by RNase mismatch cleavage.
nork: Gibbons, R, et al.
Argitaratua: (1997)

ATRX targets variable number tandem repeats and thereby influences allele-specific expression
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Argitaratua: (2010)

Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains.
nork: Picketts, D, et al.
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Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations.
nork: Steensma, D, et al.
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Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
nork: Eustermann, S, et al.
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ATRX dysfunction induces replication defects in primary mouse cells.
nork: David Clynes, et al.
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Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin
nork: Eustermann, S, et al.
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Disruption of ATRX in mouse by conditional knockout.
nork: Gibbons, R, et al.
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Functional significance of mutations in the Snf2 domain of ATRX.
nork: Mitson, M, et al.
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Neurodevelopmental Disorders Caused by Defective Chromatin Remodeling: Phenotypic Complexity Is Highlighted by a Review of ATRX Function
nork: Sara Timpano, et al.
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alpha-thalassaemia, X-linked mental retardation syndrome protein, ATRX, interacts with ribosomal genes.
nork: Law, M, et al.
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A nonsense mutation of the ATRX gene causing mild mental retardation and epilepsy.
nork: Guerrini, R, et al.
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How to tackle challenging ChIP-Seq, with long-range cross-linking, using ATRX as an example
nork: Truch, J, et al.
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Nuclear Distribution of the Chromatin-Remodeling Protein ATRX in Mouse Early Embryos during Normal Development and Developmental Arrest In Vitro
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Mutations in the human ATRX gene, encoding a putative transcription regulator, cause diverse changes in the pattern of DNA methylation.
nork: Garrick, D, et al.
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A novel mutation in the last exon of ATRX in a patient with alpha-thalassemia myelodysplastic syndrome.
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Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
nork: Garrick, D, et al.
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Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
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Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes.
nork: Qiao, Y, et al.
Argitaratua: (2014)