The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain
Depression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology. 5-HT4 receptor agonists show promise in both animal models...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Frontiers Media
2022
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| _version_ | 1826307603639042048 |
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| author | de Cates, AN Martens, MAG Wright, LC Gould van Praag, CD Capitão, LP Gibson, D Cowen, PJ Harmer, CJ Murphy, SE |
| author_facet | de Cates, AN Martens, MAG Wright, LC Gould van Praag, CD Capitão, LP Gibson, D Cowen, PJ Harmer, CJ Murphy, SE |
| author_sort | de Cates, AN |
| collection | OXFORD |
| description | Depression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology. 5-HT4 receptor agonists show promise in both animal models of depression and cognitive deficit. We therefore studied the effect of the 5-HT4 partial agonist prucalopride (1 mg daily for 6 days) on the neural processing of emotional faces in 43 healthy participants using a randomised placebo-controlled design. Participants receiving prucalopride were more accurate at identifying the gender of emotional faces. In whole brain analyses, prucalopride was also associated with reduced activation in a network of regions corresponding to the default mode network. However, there was no evidence that prucalopride treatment produced a positive bias in the neural processing of emotional faces. Our study provides further support for a pro-cognitive effect of 5-HT4 receptor agonism in humans. While our current behavioural and neural investigations do not suggest an antidepressant-like profile of prucalopride in humans, it will be important to study a wider dose range in future studies. |
| first_indexed | 2024-03-07T07:05:35Z |
| format | Journal article |
| id | oxford-uuid:fbb67541-956c-4226-85b4-269c59a6de3c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:05:35Z |
| publishDate | 2022 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:fbb67541-956c-4226-85b4-269c59a6de3c2022-04-25T12:10:06ZThe effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brainJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fbb67541-956c-4226-85b4-269c59a6de3cEnglishSymplectic ElementsFrontiers Media2022de Cates, ANMartens, MAGWright, LCGould van Praag, CDCapitão, LPGibson, DCowen, PJHarmer, CJMurphy, SEDepression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology. 5-HT4 receptor agonists show promise in both animal models of depression and cognitive deficit. We therefore studied the effect of the 5-HT4 partial agonist prucalopride (1 mg daily for 6 days) on the neural processing of emotional faces in 43 healthy participants using a randomised placebo-controlled design. Participants receiving prucalopride were more accurate at identifying the gender of emotional faces. In whole brain analyses, prucalopride was also associated with reduced activation in a network of regions corresponding to the default mode network. However, there was no evidence that prucalopride treatment produced a positive bias in the neural processing of emotional faces. Our study provides further support for a pro-cognitive effect of 5-HT4 receptor agonism in humans. While our current behavioural and neural investigations do not suggest an antidepressant-like profile of prucalopride in humans, it will be important to study a wider dose range in future studies. |
| spellingShingle | de Cates, AN Martens, MAG Wright, LC Gould van Praag, CD Capitão, LP Gibson, D Cowen, PJ Harmer, CJ Murphy, SE The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain |
| title | The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain |
| title_full | The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain |
| title_fullStr | The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain |
| title_full_unstemmed | The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain |
| title_short | The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain |
| title_sort | effect of the 5 ht4 agonist prucalopride on a functional magnetic resonance imaging faces task in the healthy human brain |
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