A first clinical trial of a novel narrow spectrum kinase inhibitor TOP1288 in patients with ulcerative colitis

A first clinical trial of a novel narrow spectrum kinase inhibitor TOP1288 in patients with ulcerative colitis

TOP1288 a novel narrow spectrum kinase inhibitor (NSKI), selectively targets key kinases fundamental to inflammatory cell signalling in innate and adaptive immune responses: p38-alpha MAP kinase, Src family kinases (Src and Lck) and Syk. The present phase 1b study was designed to evaluate TOP1288�...

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Bibliographic Details
Main Authors:	Taylor, M, Duggal, A, Rowley, A, Foster, M, Sirohi, S, Solanke, Y, Walshe, C, Webber, S, Travis, S, Irving, P
Format:	Journal article
Published:	Oxford University Press 2017

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