Functional characterisation of the glucokinase regulatory protein gene variant P446L shows diminished regulation by fructose-6 phosphate resulting in increased glucokinase activity

Lignende værker

• The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.
  af: Beer, N, et al.
  Udgivet: (2009)
• The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits
  af: Beer, N, et al.
  Udgivet: (2011)
• Insights into glucokinase regulatory protein regulation from the cellular and kinetic characterisation of rare coding variants
  af: Rees, MG, et al.
  Udgivet: (2010)
• Identification and functional characterisation of novel inactivating glucokinase mutations causing GCK-MODY in Slovakia
  af: Valentinova, L, et al.
  Udgivet: (2011)
• Investigating novel mutational mechanisms for glucokinase mutations with near normal or paradoxical kinetics
  af: Tribble, N, et al.
  Udgivet: (2009)