Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo.
One of the major complications of allogeneic bone marrow transplantation is graft-versus-host disease. This can be avoided by removing the mature T cells from the marrow, most conveniently by the use of monoclonal antibodies. However, T cell purging results in an increased tendency for the recipient...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1986
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| _version_ | 1826306532466229248 |
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| author | Cobbold, S Martin, G Waldmann, H |
| author_facet | Cobbold, S Martin, G Waldmann, H |
| author_sort | Cobbold, S |
| collection | OXFORD |
| description | One of the major complications of allogeneic bone marrow transplantation is graft-versus-host disease. This can be avoided by removing the mature T cells from the marrow, most conveniently by the use of monoclonal antibodies. However, T cell purging results in an increased tendency for the recipient to reject the donor marrow. We have developed monoclonal antibodies to L3/T4 and Lyt-2 that specifically deplete functional T cell subsets in mice. We demonstrate that such reagents can be used to control both graft-versus-host disease and marrow rejection in mouse models of bone marrow transplantation across one-haplotype or two-haplotype major histocompatibility differences. Such strategies to abrogate host resistance, by administration of anti-T-cell monoclonal antibodies to the recipient, may complement marrow T cell purging for human allogeneic bone marrow transplantation. |
| first_indexed | 2024-03-07T06:49:22Z |
| format | Journal article |
| id | oxford-uuid:fc003b9f-60dd-4a5d-a595-31ce573d0706 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:49:22Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:fc003b9f-60dd-4a5d-a595-31ce573d07062022-03-27T13:17:43ZMonoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc003b9f-60dd-4a5d-a595-31ce573d0706EnglishSymplectic Elements at Oxford1986Cobbold, SMartin, GWaldmann, HOne of the major complications of allogeneic bone marrow transplantation is graft-versus-host disease. This can be avoided by removing the mature T cells from the marrow, most conveniently by the use of monoclonal antibodies. However, T cell purging results in an increased tendency for the recipient to reject the donor marrow. We have developed monoclonal antibodies to L3/T4 and Lyt-2 that specifically deplete functional T cell subsets in mice. We demonstrate that such reagents can be used to control both graft-versus-host disease and marrow rejection in mouse models of bone marrow transplantation across one-haplotype or two-haplotype major histocompatibility differences. Such strategies to abrogate host resistance, by administration of anti-T-cell monoclonal antibodies to the recipient, may complement marrow T cell purging for human allogeneic bone marrow transplantation. |
| spellingShingle | Cobbold, S Martin, G Waldmann, H Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo. |
| title | Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo. |
| title_full | Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo. |
| title_fullStr | Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo. |
| title_full_unstemmed | Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo. |
| title_short | Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo. |
| title_sort | monoclonal antibodies for the prevention of graft versus host disease and marrow graft rejection the depletion of t cell subsets in vitro and in vivo |
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