Gating multiple signals through detailed balance of excitation and inhibition in spiking networks.
Recent theoretical work has provided a basic understanding of signal propagation in networks of spiking neurons, but mechanisms for gating and controlling these signals have not been investigated previously. Here we introduce an idea for the gating of multiple signals in cortical networks that combi...
| Principais autores: | , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2009
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| _version_ | 1826306541616103424 |
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| author | Vogels, T Abbott, L |
| author_facet | Vogels, T Abbott, L |
| author_sort | Vogels, T |
| collection | OXFORD |
| description | Recent theoretical work has provided a basic understanding of signal propagation in networks of spiking neurons, but mechanisms for gating and controlling these signals have not been investigated previously. Here we introduce an idea for the gating of multiple signals in cortical networks that combines principles of signal propagation with aspects of balanced networks. Specifically, we studied networks in which incoming excitatory signals are normally cancelled by locally evoked inhibition, leaving the targeted layer unresponsive. Transmission can be gated 'on' by modulating excitatory and inhibitory gains to upset this detailed balance. We illustrate gating through detailed balance in large networks of integrate-and-fire neurons. We show successful gating of multiple signals and study failure modes that produce effects reminiscent of clinically observed pathologies. Provided that the individual signals are detectable, detailed balance has a large capacity for gating multiple signals. |
| first_indexed | 2024-03-07T06:49:30Z |
| format | Journal article |
| id | oxford-uuid:fc0a64db-25b6-4692-8cae-679f3553e7a1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:49:30Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:fc0a64db-25b6-4692-8cae-679f3553e7a12022-03-27T13:18:07ZGating multiple signals through detailed balance of excitation and inhibition in spiking networks.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc0a64db-25b6-4692-8cae-679f3553e7a1EnglishSymplectic Elements at Oxford2009Vogels, TAbbott, LRecent theoretical work has provided a basic understanding of signal propagation in networks of spiking neurons, but mechanisms for gating and controlling these signals have not been investigated previously. Here we introduce an idea for the gating of multiple signals in cortical networks that combines principles of signal propagation with aspects of balanced networks. Specifically, we studied networks in which incoming excitatory signals are normally cancelled by locally evoked inhibition, leaving the targeted layer unresponsive. Transmission can be gated 'on' by modulating excitatory and inhibitory gains to upset this detailed balance. We illustrate gating through detailed balance in large networks of integrate-and-fire neurons. We show successful gating of multiple signals and study failure modes that produce effects reminiscent of clinically observed pathologies. Provided that the individual signals are detectable, detailed balance has a large capacity for gating multiple signals. |
| spellingShingle | Vogels, T Abbott, L Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. |
| title | Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. |
| title_full | Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. |
| title_fullStr | Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. |
| title_full_unstemmed | Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. |
| title_short | Gating multiple signals through detailed balance of excitation and inhibition in spiking networks. |
| title_sort | gating multiple signals through detailed balance of excitation and inhibition in spiking networks |
| work_keys_str_mv | AT vogelst gatingmultiplesignalsthroughdetailedbalanceofexcitationandinhibitioninspikingnetworks AT abbottl gatingmultiplesignalsthroughdetailedbalanceofexcitationandinhibitioninspikingnetworks |