From structure to clinic: design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

From structure to clinic: design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

Current therapies for Alzheimer’s disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative approach is to directly activate cholinergic receptor...

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Bibliographic Details
Main Authors: Brown, AJH, Bradley, SJ, Marshall, FH, Brown, GA, Bennett, KA, Brown, J, Cansfield, JE, Cross, DM, Dias, JM, Errey, JC, Hurrell, E, Liptrot, J, Molloy, C, Nathan, PJ, Okrasa, K, Osbourne, G, Patel, JC, Pickworth, M, Robertson, N, Shahabi, S, Bundgaard, C, Phillips, K, Broad, LM, Goonawardena, AV, Morairty, SR, Browning, M, Perini, F, Dawson, GR, Deakin, JFW, Smith, RT, Sexton, PM, Warneck, J, Vinson, M, Tasker, T, Tehan, BG, Teobald, B, Christopoulos, A, Langmead, CJ, Jazayeri, A, Cooke, RM, Rucktooa, P, Congreve, MS, Weir, M, Tobin, A, Et al.
Format: Journal article
Language:English
Published: Cell Press 2021

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