Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.
The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi- and bipotent hematopoiet...
| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
2014
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| _version_ | 1826306551344791552 |
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| author | Grover, A Mancini, E Moore, S Mead, A Atkinson, D Rasmussen, K O'Carroll, D Jacobsen, SE Nerlov, C |
| author_facet | Grover, A Mancini, E Moore, S Mead, A Atkinson, D Rasmussen, K O'Carroll, D Jacobsen, SE Nerlov, C |
| author_sort | Grover, A |
| collection | OXFORD |
| description | The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi- and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid and decreased myeloid HSC output. Epo, therefore, has a lineage instructive role in vivo, through suppression of non-erythroid fate options, demonstrating the ability of a cytokine to systematically bias successive lineage choices in favor of the generation of a specific cell type. |
| first_indexed | 2024-03-07T06:49:39Z |
| format | Journal article |
| id | oxford-uuid:fc190921-e951-4648-9ffd-acd57266c17b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:49:39Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:fc190921-e951-4648-9ffd-acd57266c17b2022-03-27T13:18:23ZErythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc190921-e951-4648-9ffd-acd57266c17bEnglishSymplectic Elements at Oxford2014Grover, AMancini, EMoore, SMead, AAtkinson, DRasmussen, KO'Carroll, DJacobsen, SENerlov, CThe erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi- and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid and decreased myeloid HSC output. Epo, therefore, has a lineage instructive role in vivo, through suppression of non-erythroid fate options, demonstrating the ability of a cytokine to systematically bias successive lineage choices in favor of the generation of a specific cell type. |
| spellingShingle | Grover, A Mancini, E Moore, S Mead, A Atkinson, D Rasmussen, K O'Carroll, D Jacobsen, SE Nerlov, C Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. |
| title | Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. |
| title_full | Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. |
| title_fullStr | Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. |
| title_full_unstemmed | Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. |
| title_short | Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. |
| title_sort | erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate |
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