Longitudinal study to assess the quantitative use of fundus autofluorescence for monitoring disease progression in choroideremia

Longitudinal study to assess the quantitative use of fundus autofluorescence for monitoring disease progression in choroideremia

<strong>Background:</strong> Characterisation of preserved autofluorescence (PAF) area in choroideremia (CHM) and its validity for monitoring disease progression in clinical trials is of importance. <strong>Methods:</strong> Eighty patients with molecularly confirmed CHM wer...

Full description

Bibliographic Details
Main Authors:	Dubis, AM, Lim, WS, Jolly, JK, Toms, M, MacLaren, RE, Webster, AR, Moosajee, M
Format:	Journal article
Language:	English
Published:	MDPI 2021

Similar Items

A qualitative and quantitative assessment of fundus autofluorescence patterns in patients with choroideremia
by: Jolly, J, et al.
Published: (2016)

Structural and functional characteristics of color vision changes in choroideremia
by: Jolly, JK, et al.
Published: (2021)

Correlation of optical coherence tomography and autofluorescence in the outer retina and choroid of patients with choroideremia
by: Xue, K, et al.
Published: (2016)

Low luminance visual acuity and low luminance deficit in choroideremia and RPGR-associated retinitis pigmentosa
by: Wood, LJ, et al.
Published: (2021)

A novel method for quantitative serial autofluorescence analysis in retinitis pigmentosa using image characteristics
by: Jolly, J, et al.
Published: (2016)

Functional defects in color vision in patients with choroideremia
by: Jolly, J, et al.
Published: (2015)

Fundus autofluorescence in patients with leber congenital amaurosis.
by: Scholl, H, et al.
Published: (2004)

Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration.
by: Charbel Issa, P, et al.
Published: (2012)

Potential lifetime quality of life benefits of choroideremia gene therapy: projections from a clinically informed decision model
by: Halioua-Haubold, C-L, et al.
Published: (2019)

The spectrum of CHM gene mutations in choroideremia and their relationship to clinical phenotype
by: Simunovic, M, et al.
Published: (2016)

Characterizing the natural history of visual function in choroideremia using microperimetry and multimodal retinal imaging
by: Jolly, J, et al.
Published: (2017)

Macular hole surgery in patients with end-stage choroideremia
by: Zinkernagel, MS, et al.
Published: (2013)

Fundus autofluorescence in the Abca4-/- mouse model of stargardt disease-correlation with accumulation of A2E, retinal function, and histology
by: Charbel Issa, P, et al.
Published: (2013)

Colour discrimination ellipses in choroideremia
by: Seitz, IP, et al.
Published: (2018)

Retinal degeneration in choroideremia follows an exponential decay function
by: Aylward, J, et al.
Published: (2018)

Choroideremia: molecular mechanisms and development of AAV gene therapy
by: Patrício, M, et al.
Published: (2018)

Visual acuity after retinal gene therapy for Choroideremia
by: Edwards, T, et al.
Published: (2016)

Prenylation of rab6a as a potency assay for choroideremia gene therapy
by: Patricio, M, et al.
Published: (2017)

Novel non-contiguous exon duplication in choroideremia
by: Edwards, T, et al.
Published: (2017)

Is subretinal AAV gene replacement still the only viable treatment option for choroideremia?
by: Han, RC, et al.
Published: (2021)

Potential CRISPR base editing therapeutic options in a Sorsby fundus dystrophy patient
by: Elsayed, MEAA, et al.
Published: (2022)

A dual variable Markov model to assess the potential benefits of choroideremia gene therapy on quality adjusted life years (QALYs)
by: Halioua-Haubold, C, et al.
Published: (2018)

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia
by: Xue, K, et al.
Published: (2018)

A detailed in vivo analysis of the retinal nerve fibre layer in choroideremia
by: Fu, D, et al.
Published: (2018)

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema.
by: Waldstein, S, et al.
Published: (2012)

"Cone dystrophy with supernormal rod electroretinogram": a comprehensive genotype/phenotype study including fundus autofluorescence and extensive electrophysiology.
by: Robson, A, et al.
Published: (2010)

Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology.
by: Charbel Issa, P, et al.
Published: (2013)

Retinal gene therapy in patients with choroideremia: Initial fi ndings from a phase 1/2 clinical trial
by: MacLaren, R, et al.
Published: (2014)

Microperimetry as an outcome measure in RPGR-associated retinitis pigmentosa clinical trials
by: Taylor, LJ, et al.
Published: (2023)

Subretinal timrepigene emparvovec in adult men with choroideremia: a randomized phase 3 trial
by: MacLaren, RE, et al.
Published: (2023)

The biological activity of AAV vectors for choroideremia gene therapy can be measured by in vitro prenylation of RAB6A
by: Patrício, M, et al.
Published: (2018)

Combined Fundus Autofluorescence and Near Infrared Reflectance as Prognostic Biomarkers for Visual Acuity in Foveal-Sparing Geographic Atrophy
by: Lindner, M, et al.
Published: (2017)

Low‐contrast visual acuity versus low‐luminance visual acuity in choroideremia
by: Wood, L, et al.
Published: (2020)

Macular hole surgery in patients with end-stage choroideremia.
by: Zinkernagel, MS, et al.
Published: (2013)

Low luminance visual acuity as a clinical measure and clinical trial outcome measure: a scoping review
by: Wood, LJ, et al.
Published: (2021)

A cross-sectional study to assess the clinical utility of modern visual function assessments in patients with inherited retinal disease: a mixed methods observational study protocol
by: Taylor, LJ, et al.
Published: (2023)

Ocular gene therapy for choroideremia: clinical trials and future perspectives
by: Xue, K, et al.
Published: (2018)

Investigating the impact of asymmetric macular sensitivity on visual acuity chart reading in choroideraemia
by: Baffour‐Awuah, KA, et al.
Published: (2024)

Gene Therapy for Choroideremia Using an Adeno-Associated Viral (AAV) Vector.
by: Barnard, A, et al.
Published: (2014)

AAV2/2-CBA-REP1 Vector with WPRE Provides Functional Expression of the Transgene in Choroideremia Mouse Knock-Out and Patient Cells
by: Tolmachova, T, et al.
Published: (2012)