A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling.
A phosphine-free palladium catalyst for aqueous Suzuki-Miyaura cross-coupling is presented. The catalyst is active enough to mediate hindered, ortho-substituted biaryl couplings but mild enough for use on peptides and proteins. The Suzuki-Miyaura couplings on protein substrates are the first to proc...
| Asıl Yazarlar: | , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
2009
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| _version_ | 1826306601146908672 |
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| author | Chalker, J Wood, C Davis, B |
| author_facet | Chalker, J Wood, C Davis, B |
| author_sort | Chalker, J |
| collection | OXFORD |
| description | A phosphine-free palladium catalyst for aqueous Suzuki-Miyaura cross-coupling is presented. The catalyst is active enough to mediate hindered, ortho-substituted biaryl couplings but mild enough for use on peptides and proteins. The Suzuki-Miyaura couplings on protein substrates are the first to proceed in useful conversions. Notably, hydrophobic aryl and vinyl groups can be transferred to the protein surface without the aid of organic solvent since the aryl- and vinylboronic acids used in the coupling are water-soluble as borate salts. The convenience and activity of this catalyst prompts use in both general synthesis and bioconjugation. |
| first_indexed | 2024-03-07T06:50:25Z |
| format | Journal article |
| id | oxford-uuid:fc60dc4a-a8ad-42c3-ac2b-b5b49f86e71d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:50:25Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:fc60dc4a-a8ad-42c3-ac2b-b5b49f86e71d2022-03-27T13:20:09ZA convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc60dc4a-a8ad-42c3-ac2b-b5b49f86e71dEnglishSymplectic Elements at Oxford2009Chalker, JWood, CDavis, BA phosphine-free palladium catalyst for aqueous Suzuki-Miyaura cross-coupling is presented. The catalyst is active enough to mediate hindered, ortho-substituted biaryl couplings but mild enough for use on peptides and proteins. The Suzuki-Miyaura couplings on protein substrates are the first to proceed in useful conversions. Notably, hydrophobic aryl and vinyl groups can be transferred to the protein surface without the aid of organic solvent since the aryl- and vinylboronic acids used in the coupling are water-soluble as borate salts. The convenience and activity of this catalyst prompts use in both general synthesis and bioconjugation. |
| spellingShingle | Chalker, J Wood, C Davis, B A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling. |
| title | A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling. |
| title_full | A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling. |
| title_fullStr | A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling. |
| title_full_unstemmed | A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling. |
| title_short | A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling. |
| title_sort | convenient catalyst for aqueous and protein suzuki miyaura cross coupling |
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