A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling.

A phosphine-free palladium catalyst for aqueous Suzuki-Miyaura cross-coupling is presented. The catalyst is active enough to mediate hindered, ortho-substituted biaryl couplings but mild enough for use on peptides and proteins. The Suzuki-Miyaura couplings on protein substrates are the first to proc...

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Détails bibliographiques
Auteurs principaux: Chalker, J, Wood, C, Davis, B
Format: Journal article
Langue:English
Publié: 2009