Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.
The cell surface molecules CD4 and CD8 greatly enhance the sensitivity of T-cell antigen recognition, acting as "co-receptors" by binding to the same major histocompatibility complex (MHC) molecules as the T-cell receptor (TCR). Here we use surface plasmon resonance to study the binding of...
Príomhchruthaitheoirí: | Gao, G, Willcox, B, Wyer, JR, Boulter, J, O'Callaghan, C, Maenaka, K, Stuart, D, Jones, E, Van Der Merwe, P, Bell, J, Jakobsen, B |
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Formáid: | Journal article |
Teanga: | English |
Foilsithe / Cruthaithe: |
2000
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Míreanna comhchosúla
Míreanna comhchosúla
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T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.
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