Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei.
Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia. Infection is often associated with bacterial dissemination to distant sites, and there are many possible disease manife...
| Những tác giả chính: | , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2006
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| _version_ | 1826306607594602496 |
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| author | Wiersinga, W van der Poll, T White, N Day, N Peacock, S |
| author_facet | Wiersinga, W van der Poll, T White, N Day, N Peacock, S |
| author_sort | Wiersinga, W |
| collection | OXFORD |
| description | Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia. Infection is often associated with bacterial dissemination to distant sites, and there are many possible disease manifestations, with melioidosis septic shock being the most severe. Eradication of the organism following infection is difficult, with a slow fever-clearance time, the need for prolonged antibiotic therapy and a high rate of relapse if therapy is not completed. Mortality from melioidosis septic shock remains high despite appropriate antimicrobial therapy. Prevention of disease and a reduction in mortality and the rate of relapse are priority areas for future research efforts. Studying how the disease is acquired and the host-pathogen interactions involved will underpin these efforts; this review presents an overview of current knowledge in these areas, highlighting key topics for evaluation. |
| first_indexed | 2024-03-07T06:50:30Z |
| format | Journal article |
| id | oxford-uuid:fc68bcb5-364f-47ec-b669-2984f18303fe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:50:30Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:fc68bcb5-364f-47ec-b669-2984f18303fe2022-03-27T13:20:25ZMelioidosis: insights into the pathogenicity of Burkholderia pseudomallei.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc68bcb5-364f-47ec-b669-2984f18303feEnglishSymplectic Elements at Oxford2006Wiersinga, Wvan der Poll, TWhite, NDay, NPeacock, SBurkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia. Infection is often associated with bacterial dissemination to distant sites, and there are many possible disease manifestations, with melioidosis septic shock being the most severe. Eradication of the organism following infection is difficult, with a slow fever-clearance time, the need for prolonged antibiotic therapy and a high rate of relapse if therapy is not completed. Mortality from melioidosis septic shock remains high despite appropriate antimicrobial therapy. Prevention of disease and a reduction in mortality and the rate of relapse are priority areas for future research efforts. Studying how the disease is acquired and the host-pathogen interactions involved will underpin these efforts; this review presents an overview of current knowledge in these areas, highlighting key topics for evaluation. |
| spellingShingle | Wiersinga, W van der Poll, T White, N Day, N Peacock, S Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. |
| title | Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. |
| title_full | Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. |
| title_fullStr | Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. |
| title_full_unstemmed | Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. |
| title_short | Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. |
| title_sort | melioidosis insights into the pathogenicity of burkholderia pseudomallei |
| work_keys_str_mv | AT wiersingaw melioidosisinsightsintothepathogenicityofburkholderiapseudomallei AT vanderpollt melioidosisinsightsintothepathogenicityofburkholderiapseudomallei AT whiten melioidosisinsightsintothepathogenicityofburkholderiapseudomallei AT dayn melioidosisinsightsintothepathogenicityofburkholderiapseudomallei AT peacocks melioidosisinsightsintothepathogenicityofburkholderiapseudomallei |