α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.

α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.

The α2δ-1 subunit of voltage-gated calcium channels is upregulated after sensory nerve injury and is also the therapeutic target of gabapentinoid drugs. It is therefore likely to play a key role in the development of neuropathic pain. In this study, we have examined mice in which α2δ-1 gene expressi...

Повний опис

Бібліографічні деталі
Автори: Patel, R, Bauer, C, Nieto-Rostro, M, Margas, W, Ferron, L, Chaggar, K, Crews, K, Ramirez, J, Bennett, D, Schwartz, A, Dickenson, A, Dolphin, A
Формат: Journal article
Мова:English
Опубліковано: 2013

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