Traumatic brain injury activation of the adult subventricular zone neurogenic niche
Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previous...
| Main Authors: | , , , , , |
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| Format: | Journal article |
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Frontiers Media
2016
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| _version_ | 1826306630283689984 |
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| author | Chang, EH Adorjan, I Mundim, MV Sun, B Dizon, MLV Szele, FG |
| author_facet | Chang, EH Adorjan, I Mundim, MV Sun, B Dizon, MLV Szele, FG |
| author_sort | Chang, EH |
| collection | OXFORD |
| description | Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI. |
| first_indexed | 2024-03-07T06:50:52Z |
| format | Journal article |
| id | oxford-uuid:fc83b8f4-5815-46e0-8752-38d5237c17b5 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:50:52Z |
| publishDate | 2016 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:fc83b8f4-5815-46e0-8752-38d5237c17b52022-03-27T13:21:26ZTraumatic brain injury activation of the adult subventricular zone neurogenic nicheJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc83b8f4-5815-46e0-8752-38d5237c17b5Symplectic Elements at OxfordFrontiers Media2016Chang, EHAdorjan, IMundim, MVSun, BDizon, MLVSzele, FGTraumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI. |
| spellingShingle | Chang, EH Adorjan, I Mundim, MV Sun, B Dizon, MLV Szele, FG Traumatic brain injury activation of the adult subventricular zone neurogenic niche |
| title | Traumatic brain injury activation of the adult subventricular zone neurogenic niche |
| title_full | Traumatic brain injury activation of the adult subventricular zone neurogenic niche |
| title_fullStr | Traumatic brain injury activation of the adult subventricular zone neurogenic niche |
| title_full_unstemmed | Traumatic brain injury activation of the adult subventricular zone neurogenic niche |
| title_short | Traumatic brain injury activation of the adult subventricular zone neurogenic niche |
| title_sort | traumatic brain injury activation of the adult subventricular zone neurogenic niche |
| work_keys_str_mv | AT changeh traumaticbraininjuryactivationoftheadultsubventricularzoneneurogenicniche AT adorjani traumaticbraininjuryactivationoftheadultsubventricularzoneneurogenicniche AT mundimmv traumaticbraininjuryactivationoftheadultsubventricularzoneneurogenicniche AT sunb traumaticbraininjuryactivationoftheadultsubventricularzoneneurogenicniche AT dizonmlv traumaticbraininjuryactivationoftheadultsubventricularzoneneurogenicniche AT szelefg traumaticbraininjuryactivationoftheadultsubventricularzoneneurogenicniche |