Complement inhibitory stent coating reduces inflammation and neointima formation in New Zealand white rabbits
Purpose: The purpose of this study was to investigate the role of inflammation during stent placement and the value of complement inhibition by stent coating with C1/C3 esterase inhibitor. Inflammation has been described as a major component of restenosis occurring after stent implantation. Methods:...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797105686133342208 |
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| author | Trück, J Wendel, H Janzen, J Brehme, U Tepe, G |
| author_facet | Trück, J Wendel, H Janzen, J Brehme, U Tepe, G |
| author_sort | Trück, J |
| collection | OXFORD |
| description | Purpose: The purpose of this study was to investigate the role of inflammation during stent placement and the value of complement inhibition by stent coating with C1/C3 esterase inhibitor. Inflammation has been described as a major component of restenosis occurring after stent implantation. Methods: Animals were randomly assigned to one of 5 treatment groups and sacrificed after 4 days, and 6 weeks respectively. After 4 days uncoated bare metal control stents (C) (n=8) were compared with polyvinylpyrrolidone coated stents (P) (n=7), and after 6 weeks C stents (n=7) were compared with P stents (n=7) and P C1/C3 esterase inhibitor coated stents (PI) (n=7). AU morphometric measurements were performed on Elastica-van-Gieson stained segments, and the inflammation index (adapted from Kornowski et al.) was assessed using hematoxylin-eosin staining. Results: No acute or subacute thrombosis was observed. After 6 weeks neointima formation was 1.8±0.6 mm2 (bare stent) and 2.6±1.3 mm2 (P) in the control groups. In the treatment group (PI) neointima reduction was detectable (1.5±0.6 mm2). Inflammation was increased by P coating. In the PI stents the inflammation was significantly reduced compared to the P stents. Inflammation was noted 4 days after stent implantation with granulocytes whereas mononuclear infiltrates (lymphocytes, plasma cells) were predominant after 6 weeks. Conclusions: Inflammation is a key component of restenosis following stent administration. Inflammation can be reduced by C1/C3 esterase inhibitor coated stents. Because the hydrogel coating itself induced inflammation, this coating seems not to be the ideal for intravascular use. © Verlag PERFUSION GmbH. |
| first_indexed | 2024-03-07T06:50:52Z |
| format | Journal article |
| id | oxford-uuid:fc83be54-d290-44fc-a78c-2d3edbfe2d7a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:50:52Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:fc83be54-d290-44fc-a78c-2d3edbfe2d7a2022-03-27T13:21:20ZComplement inhibitory stent coating reduces inflammation and neointima formation in New Zealand white rabbitsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc83be54-d290-44fc-a78c-2d3edbfe2d7aEnglishSymplectic Elements at Oxford2008Trück, JWendel, HJanzen, JBrehme, UTepe, GPurpose: The purpose of this study was to investigate the role of inflammation during stent placement and the value of complement inhibition by stent coating with C1/C3 esterase inhibitor. Inflammation has been described as a major component of restenosis occurring after stent implantation. Methods: Animals were randomly assigned to one of 5 treatment groups and sacrificed after 4 days, and 6 weeks respectively. After 4 days uncoated bare metal control stents (C) (n=8) were compared with polyvinylpyrrolidone coated stents (P) (n=7), and after 6 weeks C stents (n=7) were compared with P stents (n=7) and P C1/C3 esterase inhibitor coated stents (PI) (n=7). AU morphometric measurements were performed on Elastica-van-Gieson stained segments, and the inflammation index (adapted from Kornowski et al.) was assessed using hematoxylin-eosin staining. Results: No acute or subacute thrombosis was observed. After 6 weeks neointima formation was 1.8±0.6 mm2 (bare stent) and 2.6±1.3 mm2 (P) in the control groups. In the treatment group (PI) neointima reduction was detectable (1.5±0.6 mm2). Inflammation was increased by P coating. In the PI stents the inflammation was significantly reduced compared to the P stents. Inflammation was noted 4 days after stent implantation with granulocytes whereas mononuclear infiltrates (lymphocytes, plasma cells) were predominant after 6 weeks. Conclusions: Inflammation is a key component of restenosis following stent administration. Inflammation can be reduced by C1/C3 esterase inhibitor coated stents. Because the hydrogel coating itself induced inflammation, this coating seems not to be the ideal for intravascular use. © Verlag PERFUSION GmbH. |
| spellingShingle | Trück, J Wendel, H Janzen, J Brehme, U Tepe, G Complement inhibitory stent coating reduces inflammation and neointima formation in New Zealand white rabbits |
| title | Complement inhibitory stent coating reduces inflammation and neointima formation in New Zealand white rabbits |
| title_full | Complement inhibitory stent coating reduces inflammation and neointima formation in New Zealand white rabbits |
| title_fullStr | Complement inhibitory stent coating reduces inflammation and neointima formation in New Zealand white rabbits |
| title_full_unstemmed | Complement inhibitory stent coating reduces inflammation and neointima formation in New Zealand white rabbits |
| title_short | Complement inhibitory stent coating reduces inflammation and neointima formation in New Zealand white rabbits |
| title_sort | complement inhibitory stent coating reduces inflammation and neointima formation in new zealand white rabbits |
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