Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria.
Sixty-one patients with falciparum malaria were studied prospectively to determine the plasma concentrations of the lysosomal proteinase, polymorphonuclear leucocyte elastase (PMN-elastase) and their relationship to disease severity. The patients were divided into 3 groups; severe (parasitaemia &...
| 主要な著者: | , , , , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
1992
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| _version_ | 1826306631662567424 |
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| author | Pukrittayakamee, S Clemens, R Pramoolsinsap, C Karges, H Vanijanonta, S Bunnag, D White, N |
| author_facet | Pukrittayakamee, S Clemens, R Pramoolsinsap, C Karges, H Vanijanonta, S Bunnag, D White, N |
| author_sort | Pukrittayakamee, S |
| collection | OXFORD |
| description | Sixty-one patients with falciparum malaria were studied prospectively to determine the plasma concentrations of the lysosomal proteinase, polymorphonuclear leucocyte elastase (PMN-elastase) and their relationship to disease severity. The patients were divided into 3 groups; severe (parasitaemia > 5%) or vital organ dysfunction (n = 23), moderate (parasitaemia 1%-5% without complications) (n = 15), and mild (parasitaemia < 1%) (n = 23). The mean plasma PMN-elastase level in 10 healthy Thai volunteers was 49.5 (SD = 21.6) ng/ml (range 33-65 ng/ml). Plasma PMN-elastase concentrations on admission were elevated (> 2 x SD above normal) in all patients with severe malaria and were above 100 ng/ml in 86.6% and 65% of the moderately severe and mild patients respectively. PMN-elastase levels during the first 3 hospital days were significantly higher in severe malaria compared with the other 2 groups (P = < 0.001-0.013). The levels decreased as the patients became afebrile and aparasitaemic. Admission plasma concentrations of PMN-elastase correlated directly with bilirubin (rs = 0.50, P < 0.001), serum glutamic oxalacetic transaminase (rs = 0.54, P0.001), parasite count (rs = 0.62, P < 0.001), blood urea nitrogen (rs = 0.54, P < 0.001) and inversely with antithrombin III activity (rs = 0.54, P < 0.001) and the platelet count (rs = 0.58, P < 0.001). Polymorphonuclear leucocyte activation may contribute to the pathogenesis of severe malaria. |
| first_indexed | 2024-03-07T06:50:53Z |
| format | Journal article |
| id | oxford-uuid:fc84939a-25dc-4c16-8762-f48f8d3c8642 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:50:53Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:fc84939a-25dc-4c16-8762-f48f8d3c86422022-03-27T13:21:24ZPolymorphonuclear leucocyte elastase in Plasmodium falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc84939a-25dc-4c16-8762-f48f8d3c8642EnglishSymplectic Elements at Oxford1992Pukrittayakamee, SClemens, RPramoolsinsap, CKarges, HVanijanonta, SBunnag, DWhite, NSixty-one patients with falciparum malaria were studied prospectively to determine the plasma concentrations of the lysosomal proteinase, polymorphonuclear leucocyte elastase (PMN-elastase) and their relationship to disease severity. The patients were divided into 3 groups; severe (parasitaemia > 5%) or vital organ dysfunction (n = 23), moderate (parasitaemia 1%-5% without complications) (n = 15), and mild (parasitaemia < 1%) (n = 23). The mean plasma PMN-elastase level in 10 healthy Thai volunteers was 49.5 (SD = 21.6) ng/ml (range 33-65 ng/ml). Plasma PMN-elastase concentrations on admission were elevated (> 2 x SD above normal) in all patients with severe malaria and were above 100 ng/ml in 86.6% and 65% of the moderately severe and mild patients respectively. PMN-elastase levels during the first 3 hospital days were significantly higher in severe malaria compared with the other 2 groups (P = < 0.001-0.013). The levels decreased as the patients became afebrile and aparasitaemic. Admission plasma concentrations of PMN-elastase correlated directly with bilirubin (rs = 0.50, P < 0.001), serum glutamic oxalacetic transaminase (rs = 0.54, P0.001), parasite count (rs = 0.62, P < 0.001), blood urea nitrogen (rs = 0.54, P < 0.001) and inversely with antithrombin III activity (rs = 0.54, P < 0.001) and the platelet count (rs = 0.58, P < 0.001). Polymorphonuclear leucocyte activation may contribute to the pathogenesis of severe malaria. |
| spellingShingle | Pukrittayakamee, S Clemens, R Pramoolsinsap, C Karges, H Vanijanonta, S Bunnag, D White, N Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria. |
| title | Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria. |
| title_full | Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria. |
| title_fullStr | Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria. |
| title_full_unstemmed | Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria. |
| title_short | Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria. |
| title_sort | polymorphonuclear leucocyte elastase in plasmodium falciparum malaria |
| work_keys_str_mv | AT pukrittayakamees polymorphonuclearleucocyteelastaseinplasmodiumfalciparummalaria AT clemensr polymorphonuclearleucocyteelastaseinplasmodiumfalciparummalaria AT pramoolsinsapc polymorphonuclearleucocyteelastaseinplasmodiumfalciparummalaria AT kargesh polymorphonuclearleucocyteelastaseinplasmodiumfalciparummalaria AT vanijanontas polymorphonuclearleucocyteelastaseinplasmodiumfalciparummalaria AT bunnagd polymorphonuclearleucocyteelastaseinplasmodiumfalciparummalaria AT whiten polymorphonuclearleucocyteelastaseinplasmodiumfalciparummalaria |