Aerosol-mediated non-viral lung gene therapy: The potential of aminoglycoside-based cationic liposomes

Aerosol-mediated non-viral lung gene therapy: The potential of aminoglycoside-based cationic liposomes

Aerosol lung gene therapy using non-viral delivery systems represents a credible therapeutic strategy for chronic respiratory diseases, such as cystic fibrosis (CF). Progress in CF clinical setting using the lipidic formulation GL67A has demonstrated the relevance of such a strategy while emphasizin...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Le Gall, T, Berchel, M, Davies, L, Mottais, A, Ghanem, R, Fautrel, A, Gill, D, Hyde, S, Lehn, P, Lehn, J-M, Lemiègre, L, Benvegnu, T, Jaffrès, P-A, Pitard, B, Montier, T
Format:	Journal article
Sprache:	English
Veröffentlicht:	MDPI 2021

Ähnliche Einträge

Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferase plasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure
von: Lindberg, MF, et al.
Veröffentlicht: (2015)

Antibacterial effect and DNA delivery using a combination of an arsonium-containing lipophosphoramide with an N-heterocyclic carbene-silver complex - Potential benefits for cystic fibrosis lung gene therapy
von: Mottais, A, et al.
Veröffentlicht: (2017)

Gene therapy of cystic fibrosis: plasmid DNA contribution on in vivo lipid-based transfection efficacy
von: Lindberg, M, et al.
Veröffentlicht: (2011)

A poly-functional gene delivery system for cystic fibrosis
von: Montier, T, et al.
Veröffentlicht: (2017)

Aerosol delivery of DNA/liposomes to the lung for cystic fibrosis gene therapy.
von: Davies, L, et al.
Veröffentlicht: (2014)

Liposome treatment of viral infections
von: Dwek, R, et al.
Veröffentlicht: (2011)

Intratympanic aminoglycosides for Ménière’s disease
von: Webster, K, et al.
Veröffentlicht: (2023)

Biological efficacy and toxicity of naked plasmid DNA and cationic liposome-DNA complexes in ovine lung
von: Renwick, L, et al.
Veröffentlicht: (2003)

Aminoglycoside and macrolide resistance in Burkholderia pseudomallei.
von: Simpson, A, et al.
Veröffentlicht: (1999)

MONITORING TREATMENT WITH AMINOGLYCOSIDE ANTIBIOTICS - REPLY
von: Aronson, J, et al.
Veröffentlicht: (1993)

Local Antimicrobial Therapy with Combined Aminoglycoside and Vancomycin Compared to Aminoglycoside Monotherapy in the Surgical Management of Osteomyelitis and Fracture-Related Infection
von: Unsworth, A, et al.
Veröffentlicht: (2024)

INVIVO GENE-TRANSFER TO SYNOVIUM USING CATIONIC LIPOSOMES
von: Galealauri, J, et al.
Veröffentlicht: (1993)

Non-viral CFTR gene delivery to the lungs of Cystic Fibrosis patients
von: Hyde, S
Veröffentlicht: (2013)

Viral fusion: how Flu induces dimples on liposomes.
von: Grünewald, K
Veröffentlicht: (2010)

ABC of monitoring drug therapy. Aminoglycoside antibiotics.
von: Aronson, J, et al.
Veröffentlicht: (1992)

Volumetric analysis of lamprey hydrodynamics using synthetic aperture particle image velocimetry
von: Lehn, Andrea Michelle.
Veröffentlicht: (2019)

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.
von: McLachlan, G, et al.
Veröffentlicht: (2011)

Optimizing aerosol gene delivery and expression in the ovine lung.
von: McLachlan, G, et al.
Veröffentlicht: (2007)

Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery
von: Zhang, Yunlong, et al.
Veröffentlicht: (2014)

Design and analysis of a multi-media, multi-access data network
von: Vom Lehn, John Christian
Veröffentlicht: (2005)

Interactions of environmentally-responsive nanoparticles with synthetic and biological membranes
von: Van Lehn, Reid Chi
Veröffentlicht: (2015)

Modeling the reaction mechanism of membrane penetration by striated amphiphitic gold nanoparticles
von: Van Lehn, Reid Chi
Veröffentlicht: (2010)

Cumulative CFTR expression following repeated aerosol delivery of non-viral pGM169/GL67A formulation to mouse lung
von: Alton, E, et al.
Veröffentlicht: (2012)

Extracellular DNA shields against aminoglycosides in pseudomonas aeruginosa biofilms
von: Chiang, Wen-Chi, et al.
Veröffentlicht: (2015)

Identification of transfected cell types following non-viral gene transfer to the murine lung.
von: Davies, L, et al.
Veröffentlicht: (2007)

DNA-Loaded Cationic Liposomes Efficiently Function as a Vaccine against Malarial Proteins
von: Fotoran, Wesley L., et al.
Veröffentlicht: (2018)

Cationic liposomes enable shape control in surfactant-free synthesis of biocompatible gold nanorods
von: Gudlur, Sushanth, et al.
Veröffentlicht: (2021)

DEPOSITED FRACTION OF AQUEOUS AEROSOLS IN THE HUMAN-LUNG
von: Woolman, P, et al.
Veröffentlicht: (1986)

Fitness cost and interference of Arm/Rmt aminoglycoside resistance with the RsmF housekeeping methyltransferases.
von: Gutierrez, B, et al.
Veröffentlicht: (2012)

Liposomes as vaccine adjuvants
von: Milicic, A, et al.
Veröffentlicht: (2010)

Synthetic and mechanistic approaches to biologically potent aminoglycosides via diversified aziridination patterns
von: Rujee Lorpitthaya
Veröffentlicht: (2011)

Experiments on liposome
von: Susanti.
Veröffentlicht: (2010)

Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes.
von: Davies, L, et al.
Veröffentlicht: (2008)

Grafting Charged Species to Membrane-Embedded Scaffolds Dramatically Increases the Rate of Bilayer Flipping
von: Van Lehn, Reid C., et al.
Veröffentlicht: (2017)

Communication: Lateral phase separation of mixed polymer brushes physisorbed on planar substrates
von: Van Lehn, Reid C., et al.
Veröffentlicht: (2013)

Pathway for insertion of amphiphilic nanoparticles into defect-free lipid bilayers from atomistic molecular dynamics simulations
von: Van Lehn, Reid C., et al.
Veröffentlicht: (2016)

Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: A computational study
von: Van Lehn, Reid C, et al.
Veröffentlicht: (2021)

The effects of boundary conditions on the steady-state response of three hypothetical ground-water systems-results and implications of numerical experiments /
von: 278182 Franke, O. Lehn, et al.
Veröffentlicht: (1987)

Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses.
von: Milicic, A, et al.
Veröffentlicht: (2012)

Evaluation of 16S rRNA methyltransferase gene in aminoglycosides resistant isolates of cancer patients
von: Saba Ghafoor, et al.
Veröffentlicht: (2021)