Farnesyltransferase inhibitors as radiation sensitizers.
Activation of Ras, by mutation, overexpression, or by signaling through tyrosine kinase receptors, is associated with radioresistance. Thus, therapies that inhibit Ras function could be an effective means to radiosensitize selected types of solid tumors. Inhibition of Ras prenylation using a variety...
Κύριοι συγγραφείς: | Mckenna, W, Muschel, R, Gupta, A, Hahn, S, Bernhard, E |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2002
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Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
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Farnesyltransferase inhibitors as radiation sensitizers.
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Έκδοση: (2003) -
Farnesyltransferase inhibitors as radiation sensitizers
ανά: Mckenna, W
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Farnesyltransferase inhibitors.
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Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations.
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The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
ανά: Cohen-Jonathan, E, κ.ά.
Έκδοση: (2001)