Farnesyltransferase inhibitors as radiation sensitizers.

Farnesyltransferase inhibitors as radiation sensitizers.

Näytä muut versiot (2)

Activation of Ras, by mutation, overexpression, or by signaling through tyrosine kinase receptors, is associated with radioresistance. Thus, therapies that inhibit Ras function could be an effective means to radiosensitize selected types of solid tumors. Inhibition of Ras prenylation using a variety...

Bibliografiset tiedot
Päätekijät:	Mckenna, W, Muschel, R, Gupta, A, Hahn, S, Bernhard, E
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2002

Samankaltaisia teoksia

Farnesyltransferase inhibitors as radiation sensitizers.
Tekijä: Brunner, T, et al.
Julkaistu: (2003)

Farnesyltransferase inhibitors as radiation sensitizers
Tekijä: Mckenna, W
Julkaistu: (2005)

Farnesyltransferase inhibitors.
Tekijä: Hahn, S, et al.
Julkaistu: (2001)

Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations.
Tekijä: Brunner, T, et al.
Julkaistu: (2003)

The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
Tekijä: Cohen-Jonathan, E, et al.
Julkaistu: (2001)

Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.
Tekijä: Cohen-Jonathan, E, et al.
Julkaistu: (2000)

The RAS signal transduction pathway and its role in radiation sensitivity.
Tekijä: Mckenna, W, et al.
Julkaistu: (2003)

A Phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer.
Tekijä: Hahn, S, et al.
Julkaistu: (2002)

A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer.
Tekijä: Martin, N, et al.
Julkaistu: (2004)

The use of signal transduction inhibitors with radiation
Tekijä: Mckenna, W, et al.
Julkaistu: (2006)

A phase I trial of the farnesyltransferase and geranylgeranyltransferase-I inhibitor L-778,123 (L-778) and radiotherapy for locally advanced pancreatic cancer.
Tekijä: Martin, N, et al.
Julkaistu: (2004)

Signaling inhibition with radiation in colorectal cancer: clinical trials.
Tekijä: Mckenna, W, et al.
Julkaistu: (2003)

Targeting tumor cells by enhancing radiation sensitivity.
Tekijä: Mckenna, W, et al.
Julkaistu: (2003)

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy
Tekijä: Xiaohan Dai, et al.
Julkaistu: (2020-01-01)

Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni
Tekijä: Alexandra Probst, et al.
Julkaistu: (2019-05-01)

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
Tekijä: Shao H. Yang, et al.
Julkaistu: (2010-02-01)

Ras inhibitors and radiation therapy.
Tekijä: Jones, H, et al.
Julkaistu: (2001)

Radiation sensitization by inhibition of activated Ras.
Tekijä: Brunner, T, et al.
Julkaistu: (2004)

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Tekijä: Van Voorhis, W, et al.
Julkaistu: (2007)

Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor
Tekijä: Rothstein Jay L, et al.
Julkaistu: (2008-02-01)

Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
Tekijä: Hast, M, et al.
Julkaistu: (2009)

Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase
Tekijä: Andreea Zubaș, et al.
Julkaistu: (2023-06-01)

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Tekijä: Fletcher, S, et al.
Julkaistu: (2010)

The novel ATR inhibitor VE-821 selectively sensitizes pancreatic cancer cells to radiation and chemotherapy
Tekijä: Fokas, E, et al.
Julkaistu: (2012)

Farnesyltransferase-inhibitors exert in vitro immunosuppressive capacity by inhibiting human B-cells
Tekijä: Shilei Xu, et al.
Julkaistu: (2023-11-01)

Differential co‐expression network analysis elucidated genes associated with sensitivity to farnesyltransferase inhibitor and prognosis of acute myeloid leukemia
Tekijä: Nurdan Kelesoglu, et al.
Julkaistu: (2023-12-01)

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.
Tekijä: Prevo, R, et al.
Julkaistu: (2012)

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Tekijä: Leah K. Cuddy, et al.
Julkaistu: (2022-08-01)

Virtual Lead Identification of Farnesyltransferase Inhibitors Based on Ligand and Structure-Based Pharmacophore Techniques
Tekijä: Nizar M. Mhaidat, et al.
Julkaistu: (2013-05-01)

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)
Tekijä: Gajewski Thomas F, et al.
Julkaistu: (2012-12-01)

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells
Tekijä: Husheng Ding, et al.
Julkaistu: (2014-01-01)

Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma
Tekijä: Perla Pucci, et al.
Julkaistu: (2024-04-01)

In Vitro Evaluation of Farnesyltransferase Inhibitor and its Effect in Combination with 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor against <i>Naegleria fowleri</i>
Tekijä: Hye Jee Hahn, et al.
Julkaistu: (2020-08-01)

The Ras radiation resistance pathway.
Tekijä: Gupta, A, et al.
Julkaistu: (2001)

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
Tekijä: Anna Hagemann, et al.
Julkaistu: (2022-12-01)

Exploring Protoheme IX Farnesyltransferase as an Antimalarial Drug Target
Tekijä: Edelen, Samantha Leigh
Julkaistu: (2022)

RAS-Mediated radiation resistance is not linked to MAP kinase activation in two bladder carcinoma cell lines.
Tekijä: Gupta, A, et al.
Julkaistu: (2000)

Die hard? Radiation sensitivity of cancer stem cells from established human cell lines
Tekijä: Brunner, T, et al.
Julkaistu: (2009)

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein
Tekijä: Qi Yang, et al.
Julkaistu: (2024-06-01)

Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.
Tekijä: Gupta, A, et al.
Julkaistu: (2003)