Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Expression of human leukocyte antigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and other spondyloarthropathies. However, the exact involvement of HLA-B27 in disease initiation and progression remains unclear. The homodimer theory, which proposes that HL...

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Main Authors: Lim Kam Sian, TCC, Indumathy, S, Halim, H, Greule, A, Cryle, MJ, Bowness, P, Rossjohn, J, Gras, S, Purcell, AW, Schittenhelm, RB
格式: Journal article
語言:English
出版: American Society for Biochemistry and Molecular Biology 2019