Nocturnal dipping of heart rate and blood pressure in people with HIV in Tanzania

<p>People with HIV (PWH) have a &gt;2-fold greater risk for development of cardiovascular disease (CVD), which may be associated with abnormalities in 24-h ambulatory blood pressure measurement (ABPM) profile. We conducted a nested case-control study of ABPM in 137 PWH and HIV-uninfected c...

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Những tác giả chính: Nolan, C, Reis, K, Fadhil, S, Etyang, A, Ezeomah, C, Kingery, JR, Desderius, B, Lee, M-H, Kapiga, S, Peck, RN
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Wiley 2021
Miêu tả
Tóm tắt:<p>People with HIV (PWH) have a &gt;2-fold greater risk for development of cardiovascular disease (CVD), which may be associated with abnormalities in 24-h ambulatory blood pressure measurement (ABPM) profile. We conducted a nested case-control study of ABPM in 137 PWH and HIV-uninfected controls with normal and high clinic blood pressure (BP) in Tanzania. Nocturnal non-dipping of heart rate (HR) was significantly more common among PWH than HIV-uninfected controls (<em>p</em>&nbsp;=&nbsp;.01). Nocturnal non-dipping of BP was significantly more common in PWH with normal clinic BP (<em>p</em>&nbsp;=&nbsp;.048). Clinical correlates of nocturnal non-dipping were similar in PWH and HIV-uninfected adults and included higher BMI, higher CD4<sup>+</sup>&nbsp;cell count, and high C-reactive protein for HR and markers of renal disease for BP. In conclusion, nocturnal non-dipping of both BP and HR was more common in PWH but further research is needed to determine causes and consequences of this difference.</p>