The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection.

The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection.

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Bacterial transcription is initiated after RNA polymerase (RNAP) binds to promoter DNA, melts ~14 bp around the transcription start site and forms a single-stranded "transcription bubble" within a catalytically active RNAP-DNA open complex (RP(o)). There is significant flexibility in the t...

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מידע ביבליוגרפי
Main Authors:	Robb, N, Cordes, T, Hwang, L, Gryte, K, Duchi, D, Craggs, T, Santoso, Y, Weiss, S, Ebright, R, Kapanidis, A
פורמט:	Journal article
שפה:	English
יצא לאור:	2013

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