Investigating the effects of a point mutation in the TRPC3 channel – cause of cerebellar ataxia in Moonwalker mice – on the Purkinje cells in mice
<p>The <em>Moonwalker</em> (<em>Mwk</em>) mouse is a mouse model of cerebellar ataxia that harbours a point mutation in the Trpc3 gene. TRPC3 is a non-selective cation channel, most highly expressed in the Purkinje cells of the cerebellum. The gain-of-function mutation...
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| Materyal Türü: | Tez |
| Dil: | English |
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2012
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