Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.
During mammalian spermatogenesis, male germ cells undergo a dramatic transformation, which includes a change of shape, nuclear condensation, and development of specialised structures, such as an acrosome, and a flagellum with a mitochondrial sheath. We have found a previously undescribed pharmacolog...
Main Authors: | van der Spoel, A, Jeyakumar, M, Butters, T, Charlton, H, Moore, H, Dwek, R, Platt, F |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2002
|
Similar Items
-
Alkylated imino sugars, reversible male infertility-inducing agents, do not change the genetic integrity of male mouse germ cells, despite severe deformities of spermatozoal structures.
by: Suganuma, R, et al.
Published: (2004) -
Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities.
by: Suganuma, R, et al.
Published: (2005) -
Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation.
by: Mellor, H, et al.
Published: (2003) -
Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
by: Butters, T, et al.
Published: (2005) -
Therapeutic applications of imino sugars in lysosomal storage disorders.
by: Butters, T, et al.
Published: (2003)