Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias.
AIM: Histamine H(3) receptor antagonists have been proposed as a novel therapeutic approach for the symptomatic treatment of Alzheimer's disease (AD). However, it is unclear whether there is a neurochemical basis for extending their potential use in vascular and mixed dementias. In this study,...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797105730172485632 |
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| author | Sheng, Y Lee, J Medhurst, A Wilcock, G Esiri, M Wong, P Chen, C Lai, M |
| author_facet | Sheng, Y Lee, J Medhurst, A Wilcock, G Esiri, M Wong, P Chen, C Lai, M |
| author_sort | Sheng, Y |
| collection | OXFORD |
| description | AIM: Histamine H(3) receptor antagonists have been proposed as a novel therapeutic approach for the symptomatic treatment of Alzheimer's disease (AD). However, it is unclear whether there is a neurochemical basis for extending their potential use in vascular and mixed dementias. In this study, we measured cortical H(3) receptors in patients with subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MIX). MATERIALS AND METHODS: Radioligand binding assays using [(3)H]GSK189254 were used to measure H(3) receptors in the postmortem frontal cortex, anterior cingulate gyrus and hippocampus of a cohort of longitudinally assessed SIVD, MIX and age-matched controls. RESULTS: H(3) receptor levels were unchanged in SIVD and MIX in all areas studied. Furthermore, frontal H(3) receptor densities negatively correlated with predeath assessment of cognition using Mini-Mental State Examination (MMSE) scores. CONCLUSION: Our data suggest that H(3) receptors are preserved in SIVD and MIX, thus supporting further assessments of H(3) antagonists as potential therapeutics in these dementias. |
| first_indexed | 2024-03-07T06:51:31Z |
| format | Journal article |
| id | oxford-uuid:fcb5d3aa-9619-483d-ab44-dfbaca73e895 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:51:31Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:fcb5d3aa-9619-483d-ab44-dfbaca73e8952022-03-27T13:23:02ZPreservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fcb5d3aa-9619-483d-ab44-dfbaca73e895EnglishSymplectic Elements at Oxford2012Sheng, YLee, JMedhurst, AWilcock, GEsiri, MWong, PChen, CLai, M AIM: Histamine H(3) receptor antagonists have been proposed as a novel therapeutic approach for the symptomatic treatment of Alzheimer's disease (AD). However, it is unclear whether there is a neurochemical basis for extending their potential use in vascular and mixed dementias. In this study, we measured cortical H(3) receptors in patients with subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MIX). MATERIALS AND METHODS: Radioligand binding assays using [(3)H]GSK189254 were used to measure H(3) receptors in the postmortem frontal cortex, anterior cingulate gyrus and hippocampus of a cohort of longitudinally assessed SIVD, MIX and age-matched controls. RESULTS: H(3) receptor levels were unchanged in SIVD and MIX in all areas studied. Furthermore, frontal H(3) receptor densities negatively correlated with predeath assessment of cognition using Mini-Mental State Examination (MMSE) scores. CONCLUSION: Our data suggest that H(3) receptors are preserved in SIVD and MIX, thus supporting further assessments of H(3) antagonists as potential therapeutics in these dementias. |
| spellingShingle | Sheng, Y Lee, J Medhurst, A Wilcock, G Esiri, M Wong, P Chen, C Lai, M Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. |
| title | Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. |
| title_full | Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. |
| title_fullStr | Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. |
| title_full_unstemmed | Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. |
| title_short | Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. |
| title_sort | preservation of cortical histamine h3 receptors in ischemic vascular and mixed dementias |
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