Synthesis and reactivity of α‐cumyl bromodifluoromethanesulfenate: application to the radiosynthesis of [18F]arylSCF3
A highly reactive electrophilic bromodifluoromethylthiolating reagent, α‐cumyl bromodifluoro‐methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords a large range of bromodifluor...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2019
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| _version_ | 1826306682547863552 |
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| author | Wu, J Zhao, Q Wilson, TC Verhoog, S Gouverneur, V Lu, L Shen, Q |
| author_facet | Wu, J Zhao, Q Wilson, TC Verhoog, S Gouverneur, V Lu, L Shen, Q |
| author_sort | Wu, J |
| collection | OXFORD |
| description | A highly reactive electrophilic bromodifluoromethylthiolating reagent, α‐cumyl bromodifluoro‐methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords a large range of bromodifluoromethylthiolated arenes. These compounds are amenable to various transformations including halogen exchange with [18F]KF/K222 , a process giving access to [18F]arylSCF3 in two steps from the corresponding aryl boronic pinacol esters. |
| first_indexed | 2024-03-07T06:51:40Z |
| format | Journal article |
| id | oxford-uuid:fcc4a165-2ff7-4bcf-bc19-a5258fc7c15d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:51:40Z |
| publishDate | 2019 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:fcc4a165-2ff7-4bcf-bc19-a5258fc7c15d2022-03-27T13:23:28ZSynthesis and reactivity of α‐cumyl bromodifluoromethanesulfenate: application to the radiosynthesis of [18F]arylSCF3Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fcc4a165-2ff7-4bcf-bc19-a5258fc7c15dEnglishSymplectic Elements at OxfordWiley2019Wu, JZhao, QWilson, TCVerhoog, SGouverneur, VLu, LShen, QA highly reactive electrophilic bromodifluoromethylthiolating reagent, α‐cumyl bromodifluoro‐methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords a large range of bromodifluoromethylthiolated arenes. These compounds are amenable to various transformations including halogen exchange with [18F]KF/K222 , a process giving access to [18F]arylSCF3 in two steps from the corresponding aryl boronic pinacol esters. |
| spellingShingle | Wu, J Zhao, Q Wilson, TC Verhoog, S Gouverneur, V Lu, L Shen, Q Synthesis and reactivity of α‐cumyl bromodifluoromethanesulfenate: application to the radiosynthesis of [18F]arylSCF3 |
| title | Synthesis and reactivity of α‐cumyl bromodifluoromethanesulfenate: application to the radiosynthesis of [18F]arylSCF3 |
| title_full | Synthesis and reactivity of α‐cumyl bromodifluoromethanesulfenate: application to the radiosynthesis of [18F]arylSCF3 |
| title_fullStr | Synthesis and reactivity of α‐cumyl bromodifluoromethanesulfenate: application to the radiosynthesis of [18F]arylSCF3 |
| title_full_unstemmed | Synthesis and reactivity of α‐cumyl bromodifluoromethanesulfenate: application to the radiosynthesis of [18F]arylSCF3 |
| title_short | Synthesis and reactivity of α‐cumyl bromodifluoromethanesulfenate: application to the radiosynthesis of [18F]arylSCF3 |
| title_sort | synthesis and reactivity of α cumyl bromodifluoromethanesulfenate application to the radiosynthesis of 18f arylscf3 |
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