The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics

The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics

The pore domain of the nicotinic acetylcholine receptor has been modeled as a bundle of five kinked M2 helices. Models were generated via molecular dynamics simulations incorporating restraints derived from 9-Å resolution cryoelectron microscopy data (Unwin, 1993; 1995), and from mutagenesis data th...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Sankararamakrishnan, R, Adcock, C, Sansom, M
Άλλοι συγγραφείς:	Biophysical Society
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Elsevier 1996
Θέματα:	Biophysics

Παρόμοια τεκμήρια

Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor
ανά: Smith, G, κ.ά.
Έκδοση: (1997)

The dielectric properties of water within model transbilayer pores
ανά: Sansom, M, κ.ά.
Έκδοση: (1997)

Molecular dynamics simulations of water within models of ion channels
ανά: Breed, J, κ.ά.
Έκδοση: (1996)

The alpha7 nicotinic acetylcholine receptor: molecular modelling, electrostatics, and energetics.
ανά: Amiri, S, κ.ά.
Έκδοση: (2005)

The nicotinic acetylcholine receptor: from molecular model to single-channel conductance.
ανά: Adcock, C, κ.ά.
Έκδοση: (2000)

Allosteric contributions of muscle nicotinic acetylcholine receptor residues in small-molecule interactions, disease and subunit assembly
ανά: Epstein, M
Έκδοση: (2019)

Water in channel-like cavities: structure and dynamics
ανά: Sansom, M, κ.ά.
Έκδοση: (1996)

Engineered α-hemolysin pores with chemically and genetically-fused functional proteins
ανά: Mantri, S
Έκδοση: (2013)

Engineered α-hemolysin pores with chemically and genetically-fused functional proteins
ανά: Mantri, S
Έκδοση: (2013)

Electrophysiological characterization of the human two-pore channel 2
ανά: Lam, A
Έκδοση: (2015)

Pores formed by the nicotinic receptor m2delta Peptide: a molecular dynamics simulation study.
ανά: Law, R, κ.ά.
Έκδοση: (2003)

Imaging dynamic pore-formation processes in droplet-interface bilayers
ανά: Sengel, JT
Έκδοση: (2017)

Water-mediated conformational transitions in nicotinic receptor M2 helix bundles: a molecular dynamics study
ανά: Sankararamakrishnan, R, κ.ά.
Έκδοση: (1995)

Protocols for translocation processes of flexible polymers through a pore using LAMMPS
ανά: Vrinda Garg, κ.ά.
Έκδοση: (2025-03-01)

Electrostatics studies and molecular dynamics simulations of a homology model of the Shaker K+ channel pore.
ανά: Ranatunga, K, κ.ά.
Έκδοση: (2001)

Advances in the Understanding of Two-Pore Domain TASK Potassium Channels and Their Potential as Therapeutic Targets
ανά: Xueming Fan, κ.ά.
Έκδοση: (2022-11-01)

RADON DENSITY PROFILES IN ALVEOLAR PORES: AN INTEGRAL EQUATION FORMALISM APPLICATION
ανά: J. C. Corona-Oran, κ.ά.
Έκδοση: (2023-04-01)

Matrix Pore Size Governs Escape of Human Breast Cancer Cells from a Microtumor to an Empty Cavity
ανά: Joe Tien, κ.ά.
Έκδοση: (2020-11-01)

Modelling packing interactions in parallel helix bundles: pentameric bundles of nicotinic receptor M2 helices
ανά: Sankararamakrishnan, R, κ.ά.
Έκδοση: (1995)

Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions.
ανά: Hung, A, κ.ά.
Έκδοση: (2005)

Transbilayer pores formed by β-barrels: molecular modeling of pore structures and properties
ανά: Sansom, M, κ.ά.
Έκδοση: (1995)

Imaging the assembly of the Staphylococcal pore-forming toxin alpha-Hemolysin
ανά: Thompson, J, κ.ά.
Έκδοση: (2009)

Single-molecule chemistry studies with engineered alpha-hemolysin pores
ανά: Hammerstein, A
Έκδοση: (2011)

Simulation of pulsatory liposome working using a linear approximation for transmembrane pore dynamics
ανά: Dumitru POPESCU, κ.ά.
Έκδοση: (2024-03-01)

Ion channels: structure of a molecular brake
ανά: Sansom, M
Έκδοση: (1999)

A pore-forming protein-induced surface-enhanced Raman spectroscopic strategy for dynamic tracing of cell membrane repair
ανά: Yuanjiao Yang, κ.ά.
Έκδοση: (2021-09-01)

Neuronal nicotinic acetylcholine receptors: Common molecular substrates of nicotine and alcohol dependence
ανά: Linzy M. Hendrickson, κ.ά.
Έκδοση: (2013-04-01)

Nicotinic acetylcholine receptors and epilepsy
ανά: Andrea Becchetti, κ.ά.
Έκδοση: (2023-03-01)

Alcohol and nicotinic acetylcholine receptors
ανά: Jinsong Tang, κ.ά.
Έκδοση: (2013-05-01)

Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors.
ανά: Jeppe A Olsen, κ.ά.
Έκδοση: (2014-01-01)

Structural studies of acetylcholine bound to the nicotinic acetylcholine receptor
ανά: Williamson, P, κ.ά.
Έκδοση: (2003)

Modeling Adsorption in Silica Pores via Minkowski Functionals and Molecular Electrostatic Moments
ανά: Filip Simeski, κ.ά.
Έκδοση: (2020-11-01)

A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor.
ανά: Beckstein, O, κ.ά.
Έκδοση: (2006)

Regulation of nicotinic acetylcholine receptor assembly.
ανά: Wanamaker, C, κ.ά.
Έκδοση: (2003)

Role of membrane stretch in adsorption of antiviral peptides onto lipid membranes and membrane pore formation
ανά: Chng, Choon-Peng, κ.ά.
Έκδοση: (2021)

Partition profile of the nicotinic acetylcholine receptor in lipid domains upon reconstitution[S]
ανά: Vicente Bermúdez, κ.ά.
Έκδοση: (2010-09-01)

Structure and dynamics of the pore-lining helix of the nicotinic receptor: MD simulations in water, lipid bilayers, and transbilayer bundles.
ανά: Law, R, κ.ά.
Έκδοση: (2000)

Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study
ανά: Karoline Sanches, κ.ά.
Έκδοση: (2019-11-01)

Nicotinic Acetylcholine Receptors in the Respiratory Tract
ανά: Monika I. Hollenhorst, κ.ά.
Έκδοση: (2021-10-01)

Autoimmunity to neuronal nicotinic acetylcholine receptors
ανά: Maria Pechlivanidou, κ.ά.
Έκδοση: (2023-06-01)