Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes.
Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compa...
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2005
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| _version_ | 1826306696257994752 |
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| author | Chinnery, P Elliott, H Patel, S Lambert, C Keers, S Durham, SE McCarthy, M Hitman, G Hattersley, A Walker, M |
| author_facet | Chinnery, P Elliott, H Patel, S Lambert, C Keers, S Durham, SE McCarthy, M Hitman, G Hattersley, A Walker, M |
| author_sort | Chinnery, P |
| collection | OXFORD |
| description | Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes. |
| first_indexed | 2024-03-07T06:51:53Z |
| format | Journal article |
| id | oxford-uuid:fcd4c4a1-e1b0-420e-8001-663e64efc7dc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:51:53Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:fcd4c4a1-e1b0-420e-8001-663e64efc7dc2022-03-27T13:23:58ZRole of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fcd4c4a1-e1b0-420e-8001-663e64efc7dcEnglishSymplectic Elements at Oxford2005Chinnery, PElliott, HPatel, SLambert, CKeers, SDurham, SEMcCarthy, MHitman, GHattersley, AWalker, MRecent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes. |
| spellingShingle | Chinnery, P Elliott, H Patel, S Lambert, C Keers, S Durham, SE McCarthy, M Hitman, G Hattersley, A Walker, M Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. |
| title | Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. |
| title_full | Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. |
| title_fullStr | Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. |
| title_full_unstemmed | Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. |
| title_short | Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. |
| title_sort | role of the mitochondrial dna 16184 16193 poly c tract in type 2 diabetes |
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