The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.

The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.

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To function in fusion and signaling, Rab GTPases need to be converted into their active GTP form. We previously identified the conserved Mon1-Ccz1 complex as the guanine nucleotide exchange factor (GEF) of the yeast Rab7 GTPase Ypt7. To address the possible GEF mechanism, we generated a homology mod...

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Bibliographic Details
Main Authors: Cabrera, M, Nordmann, M, Perz, A, Schmedt, D, Gerondopoulos, A, Barr, F, Piehler, J, Engelbrecht-Vandré, S, Ungermann, C
Format: Journal article
Language:English
Published: 2014

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