A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status.
A novel X-linked gene, DXS8237E, was isolated from human fetal brain cDNA, and its 3' end was mapped to within 20 kb upstream of UBE1 in Xp11.23. A 1.3-kb cDNA for DXS8237E detects homologous sequences in other mammals and a 3-kb mRNA that is widely expressed in human cell lines and mouse tissu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1996
|
| _version_ | 1826306715827568640 |
|---|---|
| author | Coleman, M Ambrose, H Carrel, L Németh, A Willard, H Davies, K |
| author_facet | Coleman, M Ambrose, H Carrel, L Németh, A Willard, H Davies, K |
| author_sort | Coleman, M |
| collection | OXFORD |
| description | A novel X-linked gene, DXS8237E, was isolated from human fetal brain cDNA, and its 3' end was mapped to within 20 kb upstream of UBE1 in Xp11.23. A 1.3-kb cDNA for DXS8237E detects homologous sequences in other mammals and a 3-kb mRNA that is widely expressed in human cell lines and mouse tissues. Sequence analysis indicated that the 1.3-kb cDNA contains the 3' end of the DXS8237E gene, but the sequence shows no significant homology to known genes. DXS8237E was shown to be subject to X inactivation in five somatic cell hybrids that contain an inactive human X chromosome but no active homologue. Since UBE1 escapes X inactivation, DXS8237E and UBE1 are the closest mapped genes with discordant X inactivation profiles. Sequences in the vicinity of these two genes may be important determinants of X inactivation status. |
| first_indexed | 2024-03-07T06:52:10Z |
| format | Journal article |
| id | oxford-uuid:fce6eee6-8586-45b4-ad69-8fdefa47591e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:52:10Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:fce6eee6-8586-45b4-ad69-8fdefa47591e2022-03-27T13:24:43ZA novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fce6eee6-8586-45b4-ad69-8fdefa47591eEnglishSymplectic Elements at Oxford1996Coleman, MAmbrose, HCarrel, LNémeth, AWillard, HDavies, KA novel X-linked gene, DXS8237E, was isolated from human fetal brain cDNA, and its 3' end was mapped to within 20 kb upstream of UBE1 in Xp11.23. A 1.3-kb cDNA for DXS8237E detects homologous sequences in other mammals and a 3-kb mRNA that is widely expressed in human cell lines and mouse tissues. Sequence analysis indicated that the 1.3-kb cDNA contains the 3' end of the DXS8237E gene, but the sequence shows no significant homology to known genes. DXS8237E was shown to be subject to X inactivation in five somatic cell hybrids that contain an inactive human X chromosome but no active homologue. Since UBE1 escapes X inactivation, DXS8237E and UBE1 are the closest mapped genes with discordant X inactivation profiles. Sequences in the vicinity of these two genes may be important determinants of X inactivation status. |
| spellingShingle | Coleman, M Ambrose, H Carrel, L Németh, A Willard, H Davies, K A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. |
| title | A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. |
| title_full | A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. |
| title_fullStr | A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. |
| title_full_unstemmed | A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. |
| title_short | A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. |
| title_sort | novel gene dxs8237e lies within 20 kb upstream of ube1 in xp11 23 and has a different x inactivation status |
| work_keys_str_mv | AT colemanm anovelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT ambroseh anovelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT carrell anovelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT nemetha anovelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT willardh anovelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT daviesk anovelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT colemanm novelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT ambroseh novelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT carrell novelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT nemetha novelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT willardh novelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus AT daviesk novelgenedxs8237elieswithin20kbupstreamofube1inxp1123andhasadifferentxinactivationstatus |